Regulatory T cells (Tregs) are a small subset of CD4+ T cells that play a critical role in maintaining self-tolerance. In contrast to conventional CD4+ T cells, Tregs express a lineage-specific transcription factor Foxp3 and possess unique functional properties that can target many different immune cells and non-immune cells through both cell-cell contact and contact-independent mechanisms. Indeed, the breakdown of those suppression has been implicated in multiple autoimmune disorders. Although the essential role of Tregs in preventing autoimmunity is well documented, their functionality in controlling the immune response against foreign antigens is less clear and even controversial. Both beneficial and detrimental impacts of Tregs have been observed in various infections and vaccination models.
In this Research Topic, we would like to focus on recent advances in the field of Tregs in infections and vaccination. We welcome the submission of Mini-reviews, Reviews, and Original Research articles focusing on the effect of Tregs on regulating the foreign immune response and pathogenesis during infection. It will also welcome manuscripts uncovering the potential role of Tregs in regulating memory B and T cell generation and highlighting the therapeutic potential of these mechanisms in future vaccine development.
This research topic welcomes submissions based on (but not limited to) the following topics:
• The role of Tregs in acute infection.
• The role of Tregs in chronic infection.
• Effects of infection on Tregs.
• Immunological memory and Tregs.
Regulatory T cells (Tregs) are a small subset of CD4+ T cells that play a critical role in maintaining self-tolerance. In contrast to conventional CD4+ T cells, Tregs express a lineage-specific transcription factor Foxp3 and possess unique functional properties that can target many different immune cells and non-immune cells through both cell-cell contact and contact-independent mechanisms. Indeed, the breakdown of those suppression has been implicated in multiple autoimmune disorders. Although the essential role of Tregs in preventing autoimmunity is well documented, their functionality in controlling the immune response against foreign antigens is less clear and even controversial. Both beneficial and detrimental impacts of Tregs have been observed in various infections and vaccination models.
In this Research Topic, we would like to focus on recent advances in the field of Tregs in infections and vaccination. We welcome the submission of Mini-reviews, Reviews, and Original Research articles focusing on the effect of Tregs on regulating the foreign immune response and pathogenesis during infection. It will also welcome manuscripts uncovering the potential role of Tregs in regulating memory B and T cell generation and highlighting the therapeutic potential of these mechanisms in future vaccine development.
This research topic welcomes submissions based on (but not limited to) the following topics:
• The role of Tregs in acute infection.
• The role of Tregs in chronic infection.
• Effects of infection on Tregs.
• Immunological memory and Tregs.
