Neurotrauma represent multifactorial problem with variety of mechanisms involved that require complex therapeutic approaches. Early investigations of pharmacological therapy along with gene and stem cell therapy are extensively evolving nowadays, although, a universal effective therapeutic agent has not yet been found. New regenerative technologies advanced with scaffolds biomaterials and small molecules providing neuroprotection, preventing the scar formation, and promoting regeneration, are actively developing to enhance the recovery after neurotrauma. In the context of brain, spinal cord, and peripheral nerve injury, regenerative gene and stem cell therapy enhanced with biomaterials and pharmacological intervention can alleviate multiple symptoms and improve function. The studies that integrate these neuroregenerative approaches, still require understanding the common mechanistic background.
In the light of this challenge, this Research Topic will focus on novel technologies in the fields of neuroregeneration, cell and gene therapy, biomaterials, micromolecules, and pharmacology, along with integration and translation of these therapeutic approaches from animal to human, addressing the effects of neurodegeneration and remodeling after neuronal injury. We expect to discuss novel therapeutic approaches to treat traumatic brain and spinal cord injury, as well as peripheral nerve injury and peripheral neuropathy. Scientists from relevant fields are invited to submit their research with the following potential, but not exhaustive, list of topics:
- Current advances in gene and stem cell therapy of neurotrauma.
- Extracellular vesicles, micromolecules, and novel biopharmaceutical approaches.
- Advances in biomaterials in therapy for neurotrauma.
- Developing new combined neuroregenerative, pharmacological, and biomaterial strategies for brain and spinal cord injuries.
- Translation of regenerative, pharmacological, and biomaterial approaches from small and large animal models to humans.
Neurotrauma represent multifactorial problem with variety of mechanisms involved that require complex therapeutic approaches. Early investigations of pharmacological therapy along with gene and stem cell therapy are extensively evolving nowadays, although, a universal effective therapeutic agent has not yet been found. New regenerative technologies advanced with scaffolds biomaterials and small molecules providing neuroprotection, preventing the scar formation, and promoting regeneration, are actively developing to enhance the recovery after neurotrauma. In the context of brain, spinal cord, and peripheral nerve injury, regenerative gene and stem cell therapy enhanced with biomaterials and pharmacological intervention can alleviate multiple symptoms and improve function. The studies that integrate these neuroregenerative approaches, still require understanding the common mechanistic background.
In the light of this challenge, this Research Topic will focus on novel technologies in the fields of neuroregeneration, cell and gene therapy, biomaterials, micromolecules, and pharmacology, along with integration and translation of these therapeutic approaches from animal to human, addressing the effects of neurodegeneration and remodeling after neuronal injury. We expect to discuss novel therapeutic approaches to treat traumatic brain and spinal cord injury, as well as peripheral nerve injury and peripheral neuropathy. Scientists from relevant fields are invited to submit their research with the following potential, but not exhaustive, list of topics:
- Current advances in gene and stem cell therapy of neurotrauma.
- Extracellular vesicles, micromolecules, and novel biopharmaceutical approaches.
- Advances in biomaterials in therapy for neurotrauma.
- Developing new combined neuroregenerative, pharmacological, and biomaterial strategies for brain and spinal cord injuries.
- Translation of regenerative, pharmacological, and biomaterial approaches from small and large animal models to humans.
