About this Research Topic
Neurodegeneration from Alzheimer’s disease, stroke, neurotrauma, and other brain diseases could lead to dementia and severe cognitive disorders. In all these conditions, the cellular and molecular mechanisms underlying the occurrence and development of neurodegeneration are expected to be fully elucidated. Recent studies suggested that these mechanisms include immune regulation, chronic inflammatory response, production and deposition of pathological proteins, blood-brain barrier damage, etc. However, there is still a lack of in-depth mechanistic study in most fields, which may limit the exploitation of novel therapeutic strategies in the future.
With the development of neuroimaging, bioinformatics, big-data technology, and next-generation sequencing technologies, interdisciplinary joint research has become the mainstream developing trend of neuroscience. For example, single-cell sequencing, transcriptome sequencing, proteome sequencing, and metabolomic profiling provide powerful tools to allow overall investigating on the cellular and molecular mechanism underlying the development of brain diseases. Neuroscientists need to cooperate with bioinformatics scientists to complete the multi-omics analysis, to obtain more opportunities to develop novel therapeutic strategies for cognitive dysfunction. Consequently, researchers should actively break the disciplinary barriers and strengthen communication between clinical and basic medical research.
In this research topic, we will focus on the frontier studies on neural immuno-inflammation response to expand the previous understanding of the pathogenesis of neurodegenerative diseases, thus exploring their precise treatments for clinical application.
We welcome research of basic study, clinical study, and bioinformatics analysis with experiments verification, and consider all submissions in the form of Original Research and Review.
This research topic focuses on, but is not limited to:
• Mechanisms in the development of neural immuno-inflammatory response and neurodegeneration after Alzheimer’s disease, chronic traumatic encephalopathy, and stroke (vascular dementia).
• Relationship and mutual influence between neural immuno-inflammatory response and neurodegeneration.
• Mechanisms in the dissemination of local brain inflammation.
• Clinical biomarkers for diagnosis or outcome prediction associated with neural immuno-inflammatory response or neurodegeneration.
• Translational research or in-vivo research of novel immuno-inflammatory therapy for neurodegeneration.
• Identify the common and disease-specific features of neural immuno-inflammatory response among various neurodegenerative diseases.
With the development of neuroimaging, bioinformatics, big-data technology, and next-generation sequencing technologies, interdisciplinary joint research has become the mainstream developing trend of neuroscience. For example, single-cell sequencing, transcriptome sequencing, proteome sequencing, and metabolomic profiling provide powerful tools to allow overall investigating on the cellular and molecular mechanism underlying the development of brain diseases. Neuroscientists need to cooperate with bioinformatics scientists to complete the multi-omics analysis, to obtain more opportunities to develop novel therapeutic strategies for cognitive dysfunction. Consequently, researchers should actively break the disciplinary barriers and strengthen communication between clinical and basic medical research.
In this research topic, we will focus on the frontier studies on neural immuno-inflammation response to expand the previous understanding of the pathogenesis of neurodegenerative diseases, thus exploring their precise treatments for clinical application.
We welcome research of basic study, clinical study, and bioinformatics analysis with experiments verification, and consider all submissions in the form of Original Research and Review.
This research topic focuses on, but is not limited to:
• Mechanisms in the development of neural immuno-inflammatory response and neurodegeneration after Alzheimer’s disease, chronic traumatic encephalopathy, and stroke (vascular dementia).
• Relationship and mutual influence between neural immuno-inflammatory response and neurodegeneration.
• Mechanisms in the dissemination of local brain inflammation.
• Clinical biomarkers for diagnosis or outcome prediction associated with neural immuno-inflammatory response or neurodegeneration.
• Translational research or in-vivo research of novel immuno-inflammatory therapy for neurodegeneration.
• Identify the common and disease-specific features of neural immuno-inflammatory response among various neurodegenerative diseases.
Keywords: immunity, inflammation, neurodegeneration, Alzheimer's disease, traumatic brain injury, chronic traumatic encephalopathy, stroke, vascular dementia
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
