Orally Inhaled and Nasal Drug Products (OINDPs) are of growing importance in the pharmaceutical domain. OINDPs have received consideration in the pharmaceutical field owing to their intrinsic benefits over traditional dosage forms. The inhalational route may increase the therapeutic potential of drug substances by overcoming key issues like low aqueous solubility, poor permeability, physiological instability, and extensive first-pass metabolism. Additionally, OINDPs can treat both local (e.g. asthma and COPD) and systemic (e.g. Parkinson's and diabetes) diseases. Inhalation efficiently delivers substances such as synthetic drugs, phytoconstituents, genes, proteins and peptides to the pulmonary airways. Undoubtedly, OINDPs present an approach to expand market opportunities for pharmaceutical companies. Therefore, this Research Topic invites research and theories that build a strong foundation of OINDPs, calling for papers involving fundamental and applied research on this theme.
This Research Topic aims to elucidate the progress made over the past few years in OINDPs and its future hurdles. This Research Topic, entitled Advances In Orally Inhaled and Nasal Drug Products in Frontiers in Pharmacology, comprises the technologies involved in the development of OINDPs; automated particle imaging techniques; mouth-throat models for realistic in vitro analysis; pharmacokinetics/pharmacodynamics of inhaled drugs and in silico studies such as flow and particle modeling of inhalers and computational fluid dynamics (CFD)-based device assessment. Briefly, we welcome submissions of articles explaining recent experimental and numerical research related to the OINDPs.
We mainly focus on articles that report recent advances in OINDPs and reviews that abridge the different scientific outcomes of OINDPs.
This Research Topic welcomes submissions of the following article types: Original Research, Methods, Perspective, General Commentary, Mini Review, and Review. Potential topics include but are not limited to the following:
• Formulation development, physicochemical characterization and pre-clinical assessment of dry powder inhalers (DPIs), including metered-dose inhalers (MDIs), soft mist inhalers (SMIs), nebulizers, and nasal products.
• A novel technique for imaging that enables chemical and morphological characterization of the individual particle in a multi-component system.
• The in silico investigations which offer an underlying mechanism of drug/carrier detachment, deagglomeration and drug deposition.
• CFD analysis which validates the inhaler device working, drug-device interactions and drug-throat interactions.
Orally Inhaled and Nasal Drug Products (OINDPs) are of growing importance in the pharmaceutical domain. OINDPs have received consideration in the pharmaceutical field owing to their intrinsic benefits over traditional dosage forms. The inhalational route may increase the therapeutic potential of drug substances by overcoming key issues like low aqueous solubility, poor permeability, physiological instability, and extensive first-pass metabolism. Additionally, OINDPs can treat both local (e.g. asthma and COPD) and systemic (e.g. Parkinson's and diabetes) diseases. Inhalation efficiently delivers substances such as synthetic drugs, phytoconstituents, genes, proteins and peptides to the pulmonary airways. Undoubtedly, OINDPs present an approach to expand market opportunities for pharmaceutical companies. Therefore, this Research Topic invites research and theories that build a strong foundation of OINDPs, calling for papers involving fundamental and applied research on this theme.
This Research Topic aims to elucidate the progress made over the past few years in OINDPs and its future hurdles. This Research Topic, entitled Advances In Orally Inhaled and Nasal Drug Products in Frontiers in Pharmacology, comprises the technologies involved in the development of OINDPs; automated particle imaging techniques; mouth-throat models for realistic in vitro analysis; pharmacokinetics/pharmacodynamics of inhaled drugs and in silico studies such as flow and particle modeling of inhalers and computational fluid dynamics (CFD)-based device assessment. Briefly, we welcome submissions of articles explaining recent experimental and numerical research related to the OINDPs.
We mainly focus on articles that report recent advances in OINDPs and reviews that abridge the different scientific outcomes of OINDPs.
This Research Topic welcomes submissions of the following article types: Original Research, Methods, Perspective, General Commentary, Mini Review, and Review. Potential topics include but are not limited to the following:
• Formulation development, physicochemical characterization and pre-clinical assessment of dry powder inhalers (DPIs), including metered-dose inhalers (MDIs), soft mist inhalers (SMIs), nebulizers, and nasal products.
• A novel technique for imaging that enables chemical and morphological characterization of the individual particle in a multi-component system.
• The in silico investigations which offer an underlying mechanism of drug/carrier detachment, deagglomeration and drug deposition.
• CFD analysis which validates the inhaler device working, drug-device interactions and drug-throat interactions.
