About this Research Topic
Metabolic alterations and defects in mitochondrial structure and function in heart failure have been well described. However, the molecular mechanisms how mitochondrial dysfunction affects cardiac function is only poorly understood. We would like to understand how defective energy conversion and redox homeostasis directly link to cardiac dysfunction and arrhythmias and how metabolic alterations link to cardiac remodeling. How can we use novel models, including induced pluripotent stem cell derived cardiomyocytes, to reveal the mechanisms by which mitochondrial dysfunctions trigger adaptive or maladaptive responses. A detailed understanding of the pathological mechanisms will guide the way to new strategies for therapeutic intervention.
The scope of this Research Topic is to reveal the molecular mechanisms, how mitochondrial dysfunction affects cardiac function and which therapeutic strategies can be deviated in this context. Researchers are invited to submit their original research articles, reviews, mini-reviews or commentaries to contribute to the following questions:
• How does impaired mitochondrial calcium handling and altered redox homeostasis affect cardiac function in aging and heart failure?
• What are the mechanistic implications of mitochondrial dynamics and changes in oxidative phosphorylation in aging and heart failure?
• How do changes in cellular NAD+/NADH ratio affect cardiac function?
• Mechano-energetic coupling: How does defective energy conversion affect cardiac contraction cycle?
• How do inherited defects in mitochondria cause cardiomyopathies?
• How can we use stem cell derived cardiomyocytes to understand the involvement of metabolism in alterations of cardiac function?
• How does alterations in mitochondrial and cellular metabolism drive cardiac remodeling in aging and heart failure?
• How do mitochondrial retrograde signaling induce compensatory responses of the cell?
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.