Currently, there is broad consensus that the brains of individuals with schizophrenia or a schizophrenia-spectrum disorder are, across the different stages of illness, characterized by subtle deviations in brain structure, e.g. larger ventricles, smaller local and global brain volumes, a thinner cortex, aberrant structural connectivity. The extent of the deviations has been linked to symptom severity and outcome, medication intake, cannabis use, IQ, and many other clinical, functional, and behavioral measures, suggesting that they may be relevant in explaining the etiology of the disease. However, an in-depth understanding of how structural brain deviations play a role in the onset and course of schizophrenia is still lacking.
The goal of this Research Topic is to increase our understanding of the role of deviant brain structure in schizophrenia by including structural Magnetic Resonance Imaging (sMRI) studies in patients with schizophrenia, to discuss the potential of sMRI to better understand the etiology of schizophrenia and its potential to be translated into clinical practice.
Topics of interest include but are not limited to;
• Structural abnormalities in the brain as novel biomarkers for screening schizophrenia patients
• Structural differences in the brain between healthy subjects and patients with schizophrenia
• Sexual dimorphism in structural differences in the brain amongst schizophrenia patients
• The link between structural brain differences and cognitive ability in schizophrenia patients
• Structural differences in the brain and state-related changes for patients with schizophrenia
Currently, there is broad consensus that the brains of individuals with schizophrenia or a schizophrenia-spectrum disorder are, across the different stages of illness, characterized by subtle deviations in brain structure, e.g. larger ventricles, smaller local and global brain volumes, a thinner cortex, aberrant structural connectivity. The extent of the deviations has been linked to symptom severity and outcome, medication intake, cannabis use, IQ, and many other clinical, functional, and behavioral measures, suggesting that they may be relevant in explaining the etiology of the disease. However, an in-depth understanding of how structural brain deviations play a role in the onset and course of schizophrenia is still lacking.
The goal of this Research Topic is to increase our understanding of the role of deviant brain structure in schizophrenia by including structural Magnetic Resonance Imaging (sMRI) studies in patients with schizophrenia, to discuss the potential of sMRI to better understand the etiology of schizophrenia and its potential to be translated into clinical practice.
Topics of interest include but are not limited to;
• Structural abnormalities in the brain as novel biomarkers for screening schizophrenia patients
• Structural differences in the brain between healthy subjects and patients with schizophrenia
• Sexual dimorphism in structural differences in the brain amongst schizophrenia patients
• The link between structural brain differences and cognitive ability in schizophrenia patients
• Structural differences in the brain and state-related changes for patients with schizophrenia