Central nervous system (CNS) has limited regenerative capability, which makes it one of the most difficult organs to repair after injury. The limited capacity of axons to regrowth and regenerate on its own, after an injury, leads to permanent functional deficits. Consequently, functional deficits persist in several conditions that involve axonal disconnection, like spinal cord injury, traumatic brain injury, stroke and optic neuropathies. Multiple factors, including the decline of intrinsic growth capacity, the inhibitory extrinsic environment, and neuronal vulnerability after lesion, contributes to regenerative failure in the adult injured CNS. A deeper understanding on the intrinsic and extrinsic molecular pathways that limits or promotes axon regeneration may pinpoint new therapeutic targets and will contribute to the development of better therapeutic approaches for CNS injury.
The scope and focus areas of the present Research Topic include but are not limited to:
- Mechanisms that limit or promote axonal regeneration;
- Functional recovery after axon regrowth and proper re-establishment of neuronal connections;
- Optic nerve regeneration in optic neuropathies, like glaucoma, aiming vision restoration.
Central nervous system (CNS) has limited regenerative capability, which makes it one of the most difficult organs to repair after injury. The limited capacity of axons to regrowth and regenerate on its own, after an injury, leads to permanent functional deficits. Consequently, functional deficits persist in several conditions that involve axonal disconnection, like spinal cord injury, traumatic brain injury, stroke and optic neuropathies. Multiple factors, including the decline of intrinsic growth capacity, the inhibitory extrinsic environment, and neuronal vulnerability after lesion, contributes to regenerative failure in the adult injured CNS. A deeper understanding on the intrinsic and extrinsic molecular pathways that limits or promotes axon regeneration may pinpoint new therapeutic targets and will contribute to the development of better therapeutic approaches for CNS injury.
The scope and focus areas of the present Research Topic include but are not limited to:
- Mechanisms that limit or promote axonal regeneration;
- Functional recovery after axon regrowth and proper re-establishment of neuronal connections;
- Optic nerve regeneration in optic neuropathies, like glaucoma, aiming vision restoration.
