Regulation of protein kinase signaling in cardiovascular disease

124.4K

views

27

authors

11

articles

Editors

2

Friederike Cuello

University Medical Center Hamburg-Eppendorf

Kristina Lorenz

Julius Maximilian University of Würzburg

Impact

About

The human genome contains about 500 protein kinase genes. Protein kinases modify an estimated 30% of the human proteome and thus regulate the majority of cellular transduction pathways. In the cardiovascular system, altered protein kinase signalling is increasingly recognized as a key driver of disease development. Recent advances unravelling structure-function-relationships, regulatory mechanisms and physiological roles of protein kinases, renders them attractive targets for the development of novel treatment strategies. These strategies include the interference with protein kinase activity in general or more specifically target disease-specific kinase functions by regulating spatial-temporal distribution, protein-protein interactions and their subcellular localization.

This research topic aims to provide an overview of the key protein kinases implicated in cardiovascular disease and their regulatory mechanisms including other protein kinases, protein phosphatases, scaffold proteins and the redox system of the cell.

The human genome contains about 500 protein kinase genes. Protein kinases modify an estimated 30% of the human proteome and thus regulate the majority of cellular transduction pathways. In the cardiovascular system, altered protein kinase signalling is increasingly recognized as a key driver of disease development. Recent advances unravelling structure-function-relationships, regulatory mechanisms and physiological roles of protein kinases, renders them attractive targets for the development of novel treatment strategies. These strategies include the interference with protein kinase activity in general or more specifically target disease-specific kinase functions by regulating spatial-temporal distribution, protein-protein interactions and their subcellular localization.

This research topic aims to provide an overview of the key protein kinases implicated in cardiovascular disease and their regulatory mechanisms including other protein kinases, protein phosphatases, scaffold proteins and the redox system of the cell.

Share

Editors

Friederike Cuello

University Medical Center Hamburg-Eppendorf

Kristina Lorenz

Julius Maximilian University of Würzburg

Impact

124,435 Total views

96,643 Article views

25,586 Article downloads

2,206 Topic views

Published In

Journal Thumbnail

Frontiers in Pharmacology

Cardiovascular and Smooth Muscle Pharmacology

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Suggest a topic