Myeloid cells are the most abundant and varied cells of the immune system. The term myeloid captures their bone marrow origin. The myeloid family includes, in order of abundance granulocytes, eosinophils, basophils, monocytes, dendritic cells, and mast cells. Myeloid cells play key roles in homeostasis and pathology. Their numbers and phenotype change depending on the disease. Despite their importance, as effector cells in both innate and adaptive immunity, there are very few diagnostic and therapeutic applications that address the complexity of the myeloid system response in pathology.
With the development of single-cell RNAseq and other multiomic technologies, we have learned a great deal about granulocyte maturation, monocyte activation, and dendritic cell subsets. The time is ripe to rationalize this information towards a clearer picture of cell subsets in each sub-family and evidence for activation within the different myeloid sub-lineages. Less studied cells such as mast cells, eosinophils, and basophils require attention.
In this Research Topic, we will address and attempt to integrate the complexity observed in the myeloid system at Multiomics and multiparametric level. We welcome the submission of Original Research, Systematic Review, Review, Mini Review, Perspective, and Opinion articles covering, but not limited to, the following sub-topics:
• Advances in multiomics and multiparametric methodology to investigate the identity of specific myeloid cells
• Evidence for multiomics and multiparametric activation signatures for myeloid subsets in pathology
• Applications of multiomics and multiparametric results applied to myeloid cells in the clinic
Topic Editor Prof. Diana Dudziak is a consultant for BioMed X and Janssen. Prof. Dudziak also received financial support from Affimed. The other Topic Editors declare no Conflicts of Interest.
Myeloid cells are the most abundant and varied cells of the immune system. The term myeloid captures their bone marrow origin. The myeloid family includes, in order of abundance granulocytes, eosinophils, basophils, monocytes, dendritic cells, and mast cells. Myeloid cells play key roles in homeostasis and pathology. Their numbers and phenotype change depending on the disease. Despite their importance, as effector cells in both innate and adaptive immunity, there are very few diagnostic and therapeutic applications that address the complexity of the myeloid system response in pathology.
With the development of single-cell RNAseq and other multiomic technologies, we have learned a great deal about granulocyte maturation, monocyte activation, and dendritic cell subsets. The time is ripe to rationalize this information towards a clearer picture of cell subsets in each sub-family and evidence for activation within the different myeloid sub-lineages. Less studied cells such as mast cells, eosinophils, and basophils require attention.
In this Research Topic, we will address and attempt to integrate the complexity observed in the myeloid system at Multiomics and multiparametric level. We welcome the submission of Original Research, Systematic Review, Review, Mini Review, Perspective, and Opinion articles covering, but not limited to, the following sub-topics:
• Advances in multiomics and multiparametric methodology to investigate the identity of specific myeloid cells
• Evidence for multiomics and multiparametric activation signatures for myeloid subsets in pathology
• Applications of multiomics and multiparametric results applied to myeloid cells in the clinic
Topic Editor Prof. Diana Dudziak is a consultant for BioMed X and Janssen. Prof. Dudziak also received financial support from Affimed. The other Topic Editors declare no Conflicts of Interest.
