Research Topic

Focus on Systemic Lupus Erythematosus

  • Submission closed.

About this Research Topic

Systemic lupus erythematosus (SLE, or lupus) is a serious systemic autoimmune disease. Patients with SLE, who most commonly are young adult women, suffer marked morbidity and loss of life expectancy due to autoimmune-mediated inflammation of multiple organs. In the absence of specific targeted therapies, the ...

Systemic lupus erythematosus (SLE, or lupus) is a serious systemic autoimmune disease. Patients with SLE, who most commonly are young adult women, suffer marked morbidity and loss of life expectancy due to autoimmune-mediated inflammation of multiple organs. In the absence of specific targeted therapies, the majority of patients suffer inadequate disease control: a 20 year old diagnosed with SLE has a 10% chance of death before turning 40. Thus, the unmet need for more effective therapies in SLE is profound. The aetiology of SLE is multifactorial, with both genetic and environmental factors at play and roles for both the innate and adaptive immune system. While autoimmunity is critical to the initiation of SLE, morbidity and mortality are due to organ damage, mediated by the inflammation driven by pro-inflammatory cytokines.

The Aim of this research topic is to bring together experts in SLE, both clinical and academic, to discuss the major themes in the field, including the role of cytokines, T and B cell involvement, innate immune responses, genetic factors, therapeutics (those that work and those that don't) and the future of lupus research.

We want to encourage discussion and collaboration, to highlight the promising discoveries; to remind the clinicians that there is immunology behind the disease and to remind the immunologists that there is a disease behind the immunology.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Recent Articles

Loading..

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..

Comments

Loading..

Add a comment

Add comment
Back to top