Substance abuse is a widely concerned social and public health problem with large health and economic burdens. The category of substance abuse includes alcohol, tobacco, narcotics, psychotropic substances, psychostimulant, etc., and the category and prevalence are getting wider and larger. Together, they share many common pharmacological properties, such as active transport process across the blood-brain barrier, influence on transmitters release and synthesis, affect neuronal and glial activity, and modulate the expression of genes involved in neuroplasticity. Repeated administration of these substances may produce long-lasting deleterious effects. However, the underlying cellular and molecular pathophysiology mechanisms remain largely unknown despite recent increasing awareness of hazards in experimental and clinical neuroscience.
The nervous system is one of the most affected organs attacked by substance abuse and multiple neural networks in the brain are involved in the occurrence of various neurological and neuropsychiatric symptoms. The unfavorable outcome associated with substance abuse includes depression, anxiety, bipolar disorder, attention deficit and hyperactivity disorder, schizophrenia, Parkinson's disease, Alzheimer's disease, epilepsy, migraine, etc. The disease manifestations caused by various substances have associated affected brain regions that suffered multiple levels of injuries. The identification of the cellular and molecular pathophysiology mechanisms underlying substance abuse-induced nervous system injury could not only deepen the understanding of the pathophysiological mechanism but also lead to the development of new medications and other therapeutics for the targeted interventions in substance abuse-induced neurological injury.
This Research Topic warmly welcomes submissions from the researchers in the form of Original Research or Review articles that aim to consolidate advances in the field of cellular and molecular pathophysiology mechanisms underlying substance abuse. The potential themes would include, but not be limited to:
• Cellular and molecular pathophysiology mechanisms underlying substance abuse induced neuropsychiatric disorders in experimental models or patients;
• Identification of potential substance abuse-related neuropsychiatric disorders biomarkers;
• Potential therapeutic solutions targeting substance abuse-induced neuropsychiatric disorders;
• Review articles on how substance abuse affects the occurrence of neuropsychiatric disorders mechanistically.
We would like to acknowledge Zhuo Wang, who has acted as coordinator and has contributed to the preparation of the proposal for this Research Topic.
Substance abuse is a widely concerned social and public health problem with large health and economic burdens. The category of substance abuse includes alcohol, tobacco, narcotics, psychotropic substances, psychostimulant, etc., and the category and prevalence are getting wider and larger. Together, they share many common pharmacological properties, such as active transport process across the blood-brain barrier, influence on transmitters release and synthesis, affect neuronal and glial activity, and modulate the expression of genes involved in neuroplasticity. Repeated administration of these substances may produce long-lasting deleterious effects. However, the underlying cellular and molecular pathophysiology mechanisms remain largely unknown despite recent increasing awareness of hazards in experimental and clinical neuroscience.
The nervous system is one of the most affected organs attacked by substance abuse and multiple neural networks in the brain are involved in the occurrence of various neurological and neuropsychiatric symptoms. The unfavorable outcome associated with substance abuse includes depression, anxiety, bipolar disorder, attention deficit and hyperactivity disorder, schizophrenia, Parkinson's disease, Alzheimer's disease, epilepsy, migraine, etc. The disease manifestations caused by various substances have associated affected brain regions that suffered multiple levels of injuries. The identification of the cellular and molecular pathophysiology mechanisms underlying substance abuse-induced nervous system injury could not only deepen the understanding of the pathophysiological mechanism but also lead to the development of new medications and other therapeutics for the targeted interventions in substance abuse-induced neurological injury.
This Research Topic warmly welcomes submissions from the researchers in the form of Original Research or Review articles that aim to consolidate advances in the field of cellular and molecular pathophysiology mechanisms underlying substance abuse. The potential themes would include, but not be limited to:
• Cellular and molecular pathophysiology mechanisms underlying substance abuse induced neuropsychiatric disorders in experimental models or patients;
• Identification of potential substance abuse-related neuropsychiatric disorders biomarkers;
• Potential therapeutic solutions targeting substance abuse-induced neuropsychiatric disorders;
• Review articles on how substance abuse affects the occurrence of neuropsychiatric disorders mechanistically.
We would like to acknowledge Zhuo Wang, who has acted as coordinator and has contributed to the preparation of the proposal for this Research Topic.
