Diabetes has an impact on cognitive function, which ranges from subtle cognitive decrements to dementia. The potential mechanisms of type 2 diabetes impacting brain health may be related to insulin resistance, mitochondrial dysfunction and oxidative stress, endothelial dysfunction and inflammation, which are aggravated in those patients with poor metabolic control. Another metabolic disease, obesity, has also been shown to impact dementia. Body composition, particularly fat distribution, is related to distinct metabolic profiles and might have different impacts on cognitive impairment and dementia. In addition, the thyroid-stimulating hormone (TSH) concentration is a risk factor for dementia. Average serum TSH concentration also pertains to negative impacts on the development and progression of cognitive function. However, the possible role of Metabolic Disease/ Metabolic Factor in cognitive impairment and dementia is still under debate, and more convincing evidence is needed to confirm the association between Metabolic Disease/ Metabolic Factor and cognitive impairment and to determine the exact mechanism linking them.
This Research Topic aims to gain an insight into several aspects of the connections between diabetes/obesity, cognition impairment and dementia in both animal models and humans, and present cutting-edge scientific advances on the early biomarker identifying patients at risk of dementia.
We welcome submissions of Original Research, Review and Mini Review on the sub-topics below regarding the endocrine aspects of cognitive disorders:
1) The role of metabolic diseases (i.e. obesity, diabetes) or metabolic factors (i.e. insulin resistance, blood glucose, uric acid, etc.) in the pathogenesis of cognitive disorders.
2) Basic studies of metabolic effects on cognitive disorders.
3) How to identify and prevent cognitive disorders from the perspective of endocrine risk factors.
Diabetes has an impact on cognitive function, which ranges from subtle cognitive decrements to dementia. The potential mechanisms of type 2 diabetes impacting brain health may be related to insulin resistance, mitochondrial dysfunction and oxidative stress, endothelial dysfunction and inflammation, which are aggravated in those patients with poor metabolic control. Another metabolic disease, obesity, has also been shown to impact dementia. Body composition, particularly fat distribution, is related to distinct metabolic profiles and might have different impacts on cognitive impairment and dementia. In addition, the thyroid-stimulating hormone (TSH) concentration is a risk factor for dementia. Average serum TSH concentration also pertains to negative impacts on the development and progression of cognitive function. However, the possible role of Metabolic Disease/ Metabolic Factor in cognitive impairment and dementia is still under debate, and more convincing evidence is needed to confirm the association between Metabolic Disease/ Metabolic Factor and cognitive impairment and to determine the exact mechanism linking them.
This Research Topic aims to gain an insight into several aspects of the connections between diabetes/obesity, cognition impairment and dementia in both animal models and humans, and present cutting-edge scientific advances on the early biomarker identifying patients at risk of dementia.
We welcome submissions of Original Research, Review and Mini Review on the sub-topics below regarding the endocrine aspects of cognitive disorders:
1) The role of metabolic diseases (i.e. obesity, diabetes) or metabolic factors (i.e. insulin resistance, blood glucose, uric acid, etc.) in the pathogenesis of cognitive disorders.
2) Basic studies of metabolic effects on cognitive disorders.
3) How to identify and prevent cognitive disorders from the perspective of endocrine risk factors.
