In partnership with the
55nd Annual American Society for Neurochemistry Meeting, the Frontiers in Molecular Neuroscience Journal announces an article collection that will highlight cutting-edge research around the theme of the Colloquium on "Inflammasomes in CNS" on Tuesday, April 12th in Roanoke.
Increasing evidence suggests that dysregulated immune and inflammatory mechanisms contribute to several neurodegenerative diseases. Such dysregulation is either because the immune defense mechanisms are attempting to respond to a prevailing threat (either self or non-self) or due to the inherent nature of immune gene(s) to undergo either grain-of- or loss-of-function. Recent genome-wide association discoveries have identified several risk genes in the immune system pathways that are known to drive the disease. While there are numerous studies showing how the immune system contributes to Alzheimer’s disease (AD), Parkinson's disease (PD), and other neurodegenerative diseases, there is still an urgent need to understand how self (e.g., misfolded protein, dysfunctional mitochondria, injury/stroke or other types of altered cellular homeostasis) and non-self (e.g., pathogens – neurotropic viruses, bacteria, or other peripherally derived triggers such as dysbiosis) could contribute to disease pathogenesis. An in-depth study on such immune-related disease modifiers can unravel novel disease-modifying drug targets for future treatment.
Based on this, this Research Topic is seeking high-quality Original Research and Review articles on advances in the immune mechanisms related to AD, PD, and related neurodegenerative diseases. We are also looking for Original Research and Systematic Reviews as well as Meta-Analyses studies on, but not limited to:
1) immune mechanisms of AD/PD and other neurodegenerative diseases
2) neuro-immune interaction in driving neurodegenerative diseases
3) self and non-self-triggers of driving innate and adaptive immune responses in neurodegenerative diseases
4) microbiome dysbiosis and AD/PD
5) metabolic risk factors driving inflammation related to AD/PD and related neurodegenerative diseases
6) infection, inflammatory responses and neurodegenerative diseases
7) therapeutic advances in targeting the immune system as a treatment for AD.
In partnership with the
55nd Annual American Society for Neurochemistry Meeting, the Frontiers in Molecular Neuroscience Journal announces an article collection that will highlight cutting-edge research around the theme of the Colloquium on "Inflammasomes in CNS" on Tuesday, April 12th in Roanoke.
Increasing evidence suggests that dysregulated immune and inflammatory mechanisms contribute to several neurodegenerative diseases. Such dysregulation is either because the immune defense mechanisms are attempting to respond to a prevailing threat (either self or non-self) or due to the inherent nature of immune gene(s) to undergo either grain-of- or loss-of-function. Recent genome-wide association discoveries have identified several risk genes in the immune system pathways that are known to drive the disease. While there are numerous studies showing how the immune system contributes to Alzheimer’s disease (AD), Parkinson's disease (PD), and other neurodegenerative diseases, there is still an urgent need to understand how self (e.g., misfolded protein, dysfunctional mitochondria, injury/stroke or other types of altered cellular homeostasis) and non-self (e.g., pathogens – neurotropic viruses, bacteria, or other peripherally derived triggers such as dysbiosis) could contribute to disease pathogenesis. An in-depth study on such immune-related disease modifiers can unravel novel disease-modifying drug targets for future treatment.
Based on this, this Research Topic is seeking high-quality Original Research and Review articles on advances in the immune mechanisms related to AD, PD, and related neurodegenerative diseases. We are also looking for Original Research and Systematic Reviews as well as Meta-Analyses studies on, but not limited to:
1) immune mechanisms of AD/PD and other neurodegenerative diseases
2) neuro-immune interaction in driving neurodegenerative diseases
3) self and non-self-triggers of driving innate and adaptive immune responses in neurodegenerative diseases
4) microbiome dysbiosis and AD/PD
5) metabolic risk factors driving inflammation related to AD/PD and related neurodegenerative diseases
6) infection, inflammatory responses and neurodegenerative diseases
7) therapeutic advances in targeting the immune system as a treatment for AD.
