Since neural function depends on information relay among neurons in the form of electrical impulses, ion channel function determines neural function. Malfunction of ion channels underlies lots of neural disorders, such as neurodegenerative diseases, epilepsy, pathological pain, and so on. Although recent advances on the biophysical, structural, and pharmacological properties of ion channels provide critical information for dissecting the involvement of ion channel function in neural function and disorders, much is unknown about the mechanism of specific ion channel contribution to neuronal function, circuiting, and behaviors. The central question we are interested in here is how the function and regulation of ion channels determine neural function and disorders.
Ion channels are central players in all kinds of physiological and pathological processes in the central nervous system. In this Research Topic, we aim to provide a broad view of the most recent advances in the field of ion channels, including structural architecture, gating, cell surface expression, signaling, and pharmacological regulation. We also wish to include the latest insights on how the function and malfunction of ion channels influence the excitation-inhibition balance of neural circuits, how the spatio-temporal expression of ion channels influences neural development and diseases.
Therefore, we would be interested in research related to ion channel involvement in physiological and pathological processes. Topics of interest include but are not limited to:
• Physical and physiological properties on ion channels, including the structural identities, channel gating, and assembly.
• Pharmacology advances in the regulation of ion channels functions, including new achievements in developing ion channel modulators.
• Insights on how specific ion channels determine the neuronal function and neural circuits and behaviors.
• How pathological and de novo mutant ion channels contribute to the neural disorders.
• New advances in exploring therapeutic intervention of neural disorders by targeting ion channels.
Since neural function depends on information relay among neurons in the form of electrical impulses, ion channel function determines neural function. Malfunction of ion channels underlies lots of neural disorders, such as neurodegenerative diseases, epilepsy, pathological pain, and so on. Although recent advances on the biophysical, structural, and pharmacological properties of ion channels provide critical information for dissecting the involvement of ion channel function in neural function and disorders, much is unknown about the mechanism of specific ion channel contribution to neuronal function, circuiting, and behaviors. The central question we are interested in here is how the function and regulation of ion channels determine neural function and disorders.
Ion channels are central players in all kinds of physiological and pathological processes in the central nervous system. In this Research Topic, we aim to provide a broad view of the most recent advances in the field of ion channels, including structural architecture, gating, cell surface expression, signaling, and pharmacological regulation. We also wish to include the latest insights on how the function and malfunction of ion channels influence the excitation-inhibition balance of neural circuits, how the spatio-temporal expression of ion channels influences neural development and diseases.
Therefore, we would be interested in research related to ion channel involvement in physiological and pathological processes. Topics of interest include but are not limited to:
• Physical and physiological properties on ion channels, including the structural identities, channel gating, and assembly.
• Pharmacology advances in the regulation of ion channels functions, including new achievements in developing ion channel modulators.
• Insights on how specific ion channels determine the neuronal function and neural circuits and behaviors.
• How pathological and de novo mutant ion channels contribute to the neural disorders.
• New advances in exploring therapeutic intervention of neural disorders by targeting ion channels.