Inflammatory response, the interaction of the immune cells and micro-environments is known to involve in minimizing impending injury or infection and restore tissue homeostasis. As known, uncontrolled inflammation may lead to Immune-Mediated Inflammatory Diseases (IMIDs). However, the development of the IMIDs is still not clear between the molecular level crossed to the cellular activation. To understand the IMIDs, researchers are looking for the development mechanism and the resolution. Recently, immune modulation and checkpoints are known to be an important function in inflammation. Hence, lots of bioactive natural products even drugs are developed to alleviate the disorder symptom, but there is still an important gap to know how the working mechanism. Therefore, it is necessary to understand the immune cell molecular mechanisms linked to the activation, regulating the inflammatory response by the bioactive natural products.
To understand the imbalanced inflammation, modulation of the immune cell activation must be an important role. The effect of the immune cell activation is usually by the micro-environment exchange. Through the inflammatory, macrophage, dendritic cells, leukocytes are important roles in the response. These cells are presenting the partial antigen to enhance the T cells activation and cytokines production which modulates the host micro-environment. Even, cellular cytokines are produced as the signals to regulate the immune system. Hence, we hope to realize that transcript and metabolism profiling identify the immune cell alternation in the inflammation, even the effect of the bioactive natural products regulating the micro-environment.
The mission of this Research Topic is to provide a forum for discussing all critical aspects of the modulation of Immune-Mediated Inflammatory Diseases (IMIDs). The form is including of review, mini-review, original articles, clinical case reports, letters to the Editor, etc. I would like to invite scientists to submit a paper focusing on “The role of bioactive natural products modulation in the Immune-Mediated Inflammatory Diseases (IMIDs)”. Molecular and metabolism mechanism of action studies are welcome as well as experiments both on animals models.
The potential topics include but are not limited to the following:
• The process of immune modulation materials development and efficiency.
• Research of the IMIDs in animal models.
• Molecular and metabolism mechanism of IMIDs
• the new immune system knowledge crossed the organisms.
• The benefits and side effects of immune therapy in the disorders.
Note: studies carried out with crude extracts/multiherbal preparations will not be considered for review. In contrast, studies that utilize highly purified, chemically characterized compounds meet the minimum criteria for investigating pharmacological effects.
Where extracts are claimed to meet such minimum criteria, chemical structure and purity must be precisely described by appropriate analytical methods (e.g. chromatography and/or mass spectrometry).
Inflammatory response, the interaction of the immune cells and micro-environments is known to involve in minimizing impending injury or infection and restore tissue homeostasis. As known, uncontrolled inflammation may lead to Immune-Mediated Inflammatory Diseases (IMIDs). However, the development of the IMIDs is still not clear between the molecular level crossed to the cellular activation. To understand the IMIDs, researchers are looking for the development mechanism and the resolution. Recently, immune modulation and checkpoints are known to be an important function in inflammation. Hence, lots of bioactive natural products even drugs are developed to alleviate the disorder symptom, but there is still an important gap to know how the working mechanism. Therefore, it is necessary to understand the immune cell molecular mechanisms linked to the activation, regulating the inflammatory response by the bioactive natural products.
To understand the imbalanced inflammation, modulation of the immune cell activation must be an important role. The effect of the immune cell activation is usually by the micro-environment exchange. Through the inflammatory, macrophage, dendritic cells, leukocytes are important roles in the response. These cells are presenting the partial antigen to enhance the T cells activation and cytokines production which modulates the host micro-environment. Even, cellular cytokines are produced as the signals to regulate the immune system. Hence, we hope to realize that transcript and metabolism profiling identify the immune cell alternation in the inflammation, even the effect of the bioactive natural products regulating the micro-environment.
The mission of this Research Topic is to provide a forum for discussing all critical aspects of the modulation of Immune-Mediated Inflammatory Diseases (IMIDs). The form is including of review, mini-review, original articles, clinical case reports, letters to the Editor, etc. I would like to invite scientists to submit a paper focusing on “The role of bioactive natural products modulation in the Immune-Mediated Inflammatory Diseases (IMIDs)”. Molecular and metabolism mechanism of action studies are welcome as well as experiments both on animals models.
The potential topics include but are not limited to the following:
• The process of immune modulation materials development and efficiency.
• Research of the IMIDs in animal models.
• Molecular and metabolism mechanism of IMIDs
• the new immune system knowledge crossed the organisms.
• The benefits and side effects of immune therapy in the disorders.
Note: studies carried out with crude extracts/multiherbal preparations will not be considered for review. In contrast, studies that utilize highly purified, chemically characterized compounds meet the minimum criteria for investigating pharmacological effects.
Where extracts are claimed to meet such minimum criteria, chemical structure and purity must be precisely described by appropriate analytical methods (e.g. chromatography and/or mass spectrometry).
