Immune-mediated kidney disease such as glomerulonephritis, IgA nephropathy, systemic lupus erythematosus (SLE) and anti-neutrophil cytoplasmic antibody–associated (ANCA-associated) vasculitis remains a leading cause of end stage kidney disease. The objective of this special issue is to understand the role of immune microenvironment and its mechanism in the kidney pathogenesis. The microenvironment of kidney involves many kinds of immune cells including macrophages, T-cells, dendritic cells, NK-cells, mast cells and fibroblasts as non-immune cells. These cells secrete various cytokines, chemokines, complement proteins and adhesion molecules and results in immune cell infiltration. The recruitment of immune/non-immune cells in the kidney microenvironment leads to the underlying immunopathologic mechanisms, which correlates with clinical outcome. Thus, in-depth understanding of immune microenvironment is needed to discover the optimal treatment option for patients suffering from kidney diseases.
Despite recent development in our understanding of immune regulation of kidney diseases, the immunopathogenesis of kidney diseases remains unclear, which is a leading cause for the lack of novel therapies and precisely targeted interventions. Current treatment strategies targets whole immune system to control kidney inflammation and rely on unspecific immunosuppressive agents with only partially efficacious and several side effects. Understanding how local immune microenvironment in kidney drives different kidney disease can lead to development of novel therapeutic approaches to treat patient with kidney diseases. The present research topic is aimed to identify and present new immunopathogenic mechanisms of kidney diseases to promote bench-to-bedside translation.
Proposed research topic is focused to address novel immunopathogenic mechanisms that regulate different kidney disease outcomes and their translational significance. The topic welcomes original research, short communications, case reports and review articles covering the following themes but not limited to:
• Kidney immune cell composition, identification of new immune cell types and their impact on kidney diseases
• Immune-mediated kidney disease
• Novel findings exploring how kidney microenvironment interact with different kidney cells and regulate progression of kidney diseases
• Immunometabolic regulation of kidney diseases
• Recent development in immune targeted therapeutic approaches to treat kidney diseases
• Epidemiological and clinical studies addressing role of immune regulation of kidney diseases
Immune-mediated kidney disease such as glomerulonephritis, IgA nephropathy, systemic lupus erythematosus (SLE) and anti-neutrophil cytoplasmic antibody–associated (ANCA-associated) vasculitis remains a leading cause of end stage kidney disease. The objective of this special issue is to understand the role of immune microenvironment and its mechanism in the kidney pathogenesis. The microenvironment of kidney involves many kinds of immune cells including macrophages, T-cells, dendritic cells, NK-cells, mast cells and fibroblasts as non-immune cells. These cells secrete various cytokines, chemokines, complement proteins and adhesion molecules and results in immune cell infiltration. The recruitment of immune/non-immune cells in the kidney microenvironment leads to the underlying immunopathologic mechanisms, which correlates with clinical outcome. Thus, in-depth understanding of immune microenvironment is needed to discover the optimal treatment option for patients suffering from kidney diseases.
Despite recent development in our understanding of immune regulation of kidney diseases, the immunopathogenesis of kidney diseases remains unclear, which is a leading cause for the lack of novel therapies and precisely targeted interventions. Current treatment strategies targets whole immune system to control kidney inflammation and rely on unspecific immunosuppressive agents with only partially efficacious and several side effects. Understanding how local immune microenvironment in kidney drives different kidney disease can lead to development of novel therapeutic approaches to treat patient with kidney diseases. The present research topic is aimed to identify and present new immunopathogenic mechanisms of kidney diseases to promote bench-to-bedside translation.
Proposed research topic is focused to address novel immunopathogenic mechanisms that regulate different kidney disease outcomes and their translational significance. The topic welcomes original research, short communications, case reports and review articles covering the following themes but not limited to:
• Kidney immune cell composition, identification of new immune cell types and their impact on kidney diseases
• Immune-mediated kidney disease
• Novel findings exploring how kidney microenvironment interact with different kidney cells and regulate progression of kidney diseases
• Immunometabolic regulation of kidney diseases
• Recent development in immune targeted therapeutic approaches to treat kidney diseases
• Epidemiological and clinical studies addressing role of immune regulation of kidney diseases
