Lipopolysaccharide (LPS) has previously been shown to elicit a strong inflammatory response when injected into veins or the peritoneal cavity, however much about its mechanism of action has yet to be alluded to. More recently, our understanding on how LPS affects the innate immune system within its environment (constant presence of symbiotic bacteria in the skin, intestinal tract, and respiratory tract) has developed and the activity of LPS in mucous membranes has attracted significant interest from across the field. These findings have demonstrated that orally and trans-dermally administered LPS has the ability to regulate innate immunity. This regulation of the innate immune system may results in the use of LPS to prevent and treat homeostatic abnormalities, for example by helping to control the macrophage network formed by tissue macrophages and the removal of senescent cells.
The maintenance of homeostasis requires proper regulation of the innate immune system. Tissue macrophages have been shown to play an essential tole in this maintenance, as well as disease prevention and treatment. The maintenance of homeostasis requires proper regulation of the innate immune system and tissue macrophages have been shown to play an essential role in this maintenance, as well as in disease prevention and treatment. Tissue macrophages, such as microglia, have been shown to prevent cognitive decline via a network of membrane-bound Macrophage colony-stimulating factor (MCSF) on blood monocytes, when induced by oral administration of LPS. Disruption of homeostasis (including when caused by ageing), is reduced and prevented by oral and transdermal administration of LPS including in the case of ageing. However, the mechanisms by which other tissue macrophages participate in homeostasis in relation to oral and transdermal administration of LPS remain to be elucidated.
A network of tissue macrophages has been proposed as a possible mechanism, but this remains largely unexplained. Therefore, the elucidation of these mechanisms may lead to an integrated understanding of the mechanisms of homeostasis, and could be useful for the prevention of aging. All kind of manuscripts including expert opinions, consensus papers, literature reviews, and original articles are welcome, focusing on these topics:
• Crosstalk between LPS and tissue macrophages
• Signal transduction between tissue macrophages and its mechanism.
• Regulation of innate immune function and its mechanism by oral and transdermal LPS
• LPS and improvement of cognitive function
• Mucosal immune sites signalling in response to LSP administration
• The effect of LPS on wound healing
• Role of LPS in hygiene hypothesis
Lipopolysaccharide (LPS) has previously been shown to elicit a strong inflammatory response when injected into veins or the peritoneal cavity, however much about its mechanism of action has yet to be alluded to. More recently, our understanding on how LPS affects the innate immune system within its environment (constant presence of symbiotic bacteria in the skin, intestinal tract, and respiratory tract) has developed and the activity of LPS in mucous membranes has attracted significant interest from across the field. These findings have demonstrated that orally and trans-dermally administered LPS has the ability to regulate innate immunity. This regulation of the innate immune system may results in the use of LPS to prevent and treat homeostatic abnormalities, for example by helping to control the macrophage network formed by tissue macrophages and the removal of senescent cells.
The maintenance of homeostasis requires proper regulation of the innate immune system. Tissue macrophages have been shown to play an essential tole in this maintenance, as well as disease prevention and treatment. The maintenance of homeostasis requires proper regulation of the innate immune system and tissue macrophages have been shown to play an essential role in this maintenance, as well as in disease prevention and treatment. Tissue macrophages, such as microglia, have been shown to prevent cognitive decline via a network of membrane-bound Macrophage colony-stimulating factor (MCSF) on blood monocytes, when induced by oral administration of LPS. Disruption of homeostasis (including when caused by ageing), is reduced and prevented by oral and transdermal administration of LPS including in the case of ageing. However, the mechanisms by which other tissue macrophages participate in homeostasis in relation to oral and transdermal administration of LPS remain to be elucidated.
A network of tissue macrophages has been proposed as a possible mechanism, but this remains largely unexplained. Therefore, the elucidation of these mechanisms may lead to an integrated understanding of the mechanisms of homeostasis, and could be useful for the prevention of aging. All kind of manuscripts including expert opinions, consensus papers, literature reviews, and original articles are welcome, focusing on these topics:
• Crosstalk between LPS and tissue macrophages
• Signal transduction between tissue macrophages and its mechanism.
• Regulation of innate immune function and its mechanism by oral and transdermal LPS
• LPS and improvement of cognitive function
• Mucosal immune sites signalling in response to LSP administration
• The effect of LPS on wound healing
• Role of LPS in hygiene hypothesis
