Mesenchymal stem or stromal cells (MSCs) represent a population of multipotent stem cells that exist in various adult tissues where they interact with immune cells and other types of resident cells involved in tissue homeostasis and repair/regeneration upon injury. MSC-based therapy is emerging as a promising approach to facilitate tissue repair/regeneration and treat various inflammatory diseases largely through their paracrine secretion of a myriad of bioactive factors with potent immunomodulatory effects on both innate and adaptive immune cells and multiple trophic effects on another type of non-immune resident cells.
Based on existing findings, the cross-talk between immune cells and MSCs plays an important role in tissue repair/regeneration and MSC-based regenerative therapy. On one hand, immune cells can modulate the homeostatic, regenerative, and therapeutic potentials of both endogenous and exogenous MSCs. On the other hand, MSCs possess potent regulatory effects on the phenotype and function of immune cells. Therefore, leveraging the cross-talks between MSCs and immune cells holds great promise to optimize the regenerative and therapeutic potentials of MSCs.
The aim of this Research Topic is to give insight into the mechanisms underlying the complicated cross-talk between MSCs and immune cells during tissue repair/regeneration. We want to provide a platform to present advances in the research on the cross-talk between immune cells and endogenous or exogenous MSCs as well as the potential mechanisms in the attempt to optimize the regenerative and therapeutic potentials of MSCs during tissue repair/regeneration.
This Research Topic welcomes articles covering, but not limited to, the following sub-topics:
1) The unique characteristics, e. g., cell surface markers, self-renewal, and multipotent differentiation capability, secretomes, etc., of MSCs, derived from different tissues or organs
2) Differences in the immunomodulatory effects on immune cells and trophic effects on various non-immune cells mediated by MSCs of different tissue-origins
3) Differences in the regenerative and therapeutic potentials of MSCs of different tissue origins under specific pathological conditions
4) The modulatory effects of different types of immune cells on the plastic properties and functions of MSCs derived from different tissues
5) Mechanism of actions of MSC-based regenerative therapies for tissue repair/regeneration and the treatment of specific inflammatory diseases
6) Optimizing the certain properties and functions of MSCs through harnessing their cross-talks with a different types of immune cells so as to improve their regenerative/therapeutic potentials for specific tissue repair/regeneration or the treatment of specific inflammatory diseases
7) The influences of MSCs on immunometabolism
Mesenchymal stem or stromal cells (MSCs) represent a population of multipotent stem cells that exist in various adult tissues where they interact with immune cells and other types of resident cells involved in tissue homeostasis and repair/regeneration upon injury. MSC-based therapy is emerging as a promising approach to facilitate tissue repair/regeneration and treat various inflammatory diseases largely through their paracrine secretion of a myriad of bioactive factors with potent immunomodulatory effects on both innate and adaptive immune cells and multiple trophic effects on another type of non-immune resident cells.
Based on existing findings, the cross-talk between immune cells and MSCs plays an important role in tissue repair/regeneration and MSC-based regenerative therapy. On one hand, immune cells can modulate the homeostatic, regenerative, and therapeutic potentials of both endogenous and exogenous MSCs. On the other hand, MSCs possess potent regulatory effects on the phenotype and function of immune cells. Therefore, leveraging the cross-talks between MSCs and immune cells holds great promise to optimize the regenerative and therapeutic potentials of MSCs.
The aim of this Research Topic is to give insight into the mechanisms underlying the complicated cross-talk between MSCs and immune cells during tissue repair/regeneration. We want to provide a platform to present advances in the research on the cross-talk between immune cells and endogenous or exogenous MSCs as well as the potential mechanisms in the attempt to optimize the regenerative and therapeutic potentials of MSCs during tissue repair/regeneration.
This Research Topic welcomes articles covering, but not limited to, the following sub-topics:
1) The unique characteristics, e. g., cell surface markers, self-renewal, and multipotent differentiation capability, secretomes, etc., of MSCs, derived from different tissues or organs
2) Differences in the immunomodulatory effects on immune cells and trophic effects on various non-immune cells mediated by MSCs of different tissue-origins
3) Differences in the regenerative and therapeutic potentials of MSCs of different tissue origins under specific pathological conditions
4) The modulatory effects of different types of immune cells on the plastic properties and functions of MSCs derived from different tissues
5) Mechanism of actions of MSC-based regenerative therapies for tissue repair/regeneration and the treatment of specific inflammatory diseases
6) Optimizing the certain properties and functions of MSCs through harnessing their cross-talks with a different types of immune cells so as to improve their regenerative/therapeutic potentials for specific tissue repair/regeneration or the treatment of specific inflammatory diseases
7) The influences of MSCs on immunometabolism
