African swine fever (ASF) is a highly contagious infectious disease caused by African swine fever virus (ASFV). The mortality rates of those ASFV-infected domestic pigs and wild boars have reached as high as 100%. Since there is no commercial vaccine available to prevent ASF, it has spread rapidly and become a great challenge for the swine industry worldwide.
ASFV encodes more than 167 proteins which not only execute their functions in virus replication but also regulate host antiviral immune responses. It was indicated that ASFV E248R and E199L were involved in membrane fusion, and DP71L, A224L, and EP424R could regulate the viral translation. Some ASFV proteins such as MGF_505-7R, E120R, DP96R, A137R, I215L, and MGF_360-12L inhibited innate immune by different mechanisms. However, the pathogenesis, immune evasion, and immune protection mechanism of ASFV are still not fully understood, which limited the development of safe and effective ASF vaccines. Therefore, it is urgent to study the molecular and cellular mechanisms of ASFV in escaping innate and adaptive immune responses in the host.
The goal of this Research Topic is to explore more insights into the pathogenesis, immune evasion, and immune protective mechanism of ASFV and to provide theoretical support for the design and development of novel effective ASFV vaccines.
We welcome the submission of Original Research articles, Reviews, Mini-Reviews, and others covering the mechanism exploration of the following (but not limited to) topics:
1) Pathogenicity of ASFV
2) Interferon production upon ASFV infection
3) JAK-STAT signaling pathway upon ASFV infection
4) Inflammatory response against ASFV
5) ASFV and autophagy
6) ASFV and cell death
7) Immune protection mechanism of ASFV
African swine fever (ASF) is a highly contagious infectious disease caused by African swine fever virus (ASFV). The mortality rates of those ASFV-infected domestic pigs and wild boars have reached as high as 100%. Since there is no commercial vaccine available to prevent ASF, it has spread rapidly and become a great challenge for the swine industry worldwide.
ASFV encodes more than 167 proteins which not only execute their functions in virus replication but also regulate host antiviral immune responses. It was indicated that ASFV E248R and E199L were involved in membrane fusion, and DP71L, A224L, and EP424R could regulate the viral translation. Some ASFV proteins such as MGF_505-7R, E120R, DP96R, A137R, I215L, and MGF_360-12L inhibited innate immune by different mechanisms. However, the pathogenesis, immune evasion, and immune protection mechanism of ASFV are still not fully understood, which limited the development of safe and effective ASF vaccines. Therefore, it is urgent to study the molecular and cellular mechanisms of ASFV in escaping innate and adaptive immune responses in the host.
The goal of this Research Topic is to explore more insights into the pathogenesis, immune evasion, and immune protective mechanism of ASFV and to provide theoretical support for the design and development of novel effective ASFV vaccines.
We welcome the submission of Original Research articles, Reviews, Mini-Reviews, and others covering the mechanism exploration of the following (but not limited to) topics:
1) Pathogenicity of ASFV
2) Interferon production upon ASFV infection
3) JAK-STAT signaling pathway upon ASFV infection
4) Inflammatory response against ASFV
5) ASFV and autophagy
6) ASFV and cell death
7) Immune protection mechanism of ASFV