Alzheimer's disease (AD) is the most prevalent and severe form of neurodegeneration. Although neurobiology has been the primary focus of the drug targets in AD, the recent partial success of anti-amyloid-beta treatment in association with reduced cognitive decline demonstrates that glia-mediated amyloid-beta clearance is a legitimate target and that may indirectly alter the neuroimmune response in AD.
There is growing evidence that glial cells (astrocytes, microglia, and oligodendrocytes) play a significant role in the modulation of disease. These emerging fields highlight the fact that the glial cell-mediated therapeutic approach will provide great potential to cure AD.
This Research Topic welcomes contributions in the form of Original Research, Review, and Opinion articles, including pre-clinical and clinical research, to explore a new therapeutic approach to the neuroimmune axis in Alzheimer’s disease. Studies of crosstalk between different cell types (ex, neural-glial and/or glial-glial) to modulate cell-cell communication including pharmacological and non-pharmacological interventions are also welcome.
Potential topics of interest include, but are not limited to the following:
•Alzheimer's disease (AD) gene study associated with the immune system (ex, TREM2, CD33, CR1, and etc)
•Crosstalk between neural-glial and/or glial-glial in Alzheimer's disease
•Crosstalk between innate and adaptive immune response
•Receptor-ligand altered interactions in Alzheimer's disease.
Alzheimer's disease (AD) is the most prevalent and severe form of neurodegeneration. Although neurobiology has been the primary focus of the drug targets in AD, the recent partial success of anti-amyloid-beta treatment in association with reduced cognitive decline demonstrates that glia-mediated amyloid-beta clearance is a legitimate target and that may indirectly alter the neuroimmune response in AD.
There is growing evidence that glial cells (astrocytes, microglia, and oligodendrocytes) play a significant role in the modulation of disease. These emerging fields highlight the fact that the glial cell-mediated therapeutic approach will provide great potential to cure AD.
This Research Topic welcomes contributions in the form of Original Research, Review, and Opinion articles, including pre-clinical and clinical research, to explore a new therapeutic approach to the neuroimmune axis in Alzheimer’s disease. Studies of crosstalk between different cell types (ex, neural-glial and/or glial-glial) to modulate cell-cell communication including pharmacological and non-pharmacological interventions are also welcome.
Potential topics of interest include, but are not limited to the following:
•Alzheimer's disease (AD) gene study associated with the immune system (ex, TREM2, CD33, CR1, and etc)
•Crosstalk between neural-glial and/or glial-glial in Alzheimer's disease
•Crosstalk between innate and adaptive immune response
•Receptor-ligand altered interactions in Alzheimer's disease.