Over the last several decades, the majority of breakthroughs in neuroscience have relied on data that was first derived from animal experiments. Animal models have, therefore, enhanced our understanding of the molecular pathogenesis of neurological disorders, and broadened the scope of neuropharmacological and neurotoxicological research. Aside from mammalian models, the importance of other vertebrate and invertebrate models is understood and has been recognized. In vivo non-mammalian models are comparatively simpler and more tractable than mammalian models. The increasing diversity of non-mammalian model species, which include Hirudo verbena, Planaria, Caenorhabditis elegans, Danio rerio, Xenopus laevis, etc. has deepened our understanding and facilitated greater research in the field.
Given their advantages over traditional rodent models, there exists a great need to utilize and explore these model organisms within the field of neuroscience. This Research Topic, therefore, aims to highlight recent advances in neuropharmacology and neurotoxicity by modeling non-mammalian animal organisms, which exhibit similar functions and mechanisms for neurological processes as complex as development, pathogenesis, etc.. This Topic will provide insights into pathogenesis of neurological disorders and their treatment, as well as the understanding of neurodevelopment and neurotoxicity.
Manuscripts submitted to this Research Topic may include, but are not limited to:
1. Modelling of neurological disorders
2. Screening/evaluation/discovery of neuroprotective/neurotoxic compounds
3. Mechanisms underlying neuroprotection/neurotoxicity
4. New neuropharmacological approaches
5. Drugs-, chemicals-, and environmental pollutants-induced neurotoxicity
6. Use of in vivo non-mammalian models in translational research
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All the manuscripts submitted to the collection will need to fully comply with the
Four Pillars of Best Practice in Ethnopharmacology (you can freely download the full version
here).