Aneurysmal subarachnoid hemorrhage (aSAH) is a severe subtype of stroke associated with high morbidity and mortality. Survival after aSAH has increased in recent decades due to early diagnosis, increasing rates of therapeutic aneurysm occlusion, and advanced care in the intensive care unit. Unfortunately, survivors still suffer from cognitive and functional impairments that significantly affect their quality of life. Many preclinical studies and clinical trials have been conducted from molecules to the real world, but few have resulted in significant improvement in outcomes. CONSCIOUS -1 is often recognized as a turning point for researchers and clinicians, showing that delayed cerebral ischemia (DCI) is a multifactorial consequence after aSAH, while the notion of early brain injury (EBI) has been strengthened since the early 2000s. The transition of research focus from DCI to EBI continues to evolve and is promising under the rapid development and introduction of novel experimental techniques, artificial intelligence, and improved study designs.
This Research Topic aims to attract cutting edge Original Research and Systematic Review, in addition to high quality narrative Reviews and meta-analyses in the area of basic and clinical studies on EBI/DCI after aSAH, contributing to a more comprehensive knowledge of these complications. We encourage submissions of laboratory experiments, as well as clinical studies describing novel mechanisms, diagnosis, and multidisciplinary treatment strategies for aSAH.
Topics of interest include:
- Potential etiology, pathogenesis, pathophysiological mechanisms for EBI/DCI following aSAH.
- Preclinical or clinical biomarkers for EBI/DCI/outcome after aSAH.
- Pilot studies and clinical trials in aSAH.
- Perioperative and intensive care multimodal monitoring and management after aSAH.
- Cognitive and functional outcomes after aSAH.
Aneurysmal subarachnoid hemorrhage (aSAH) is a severe subtype of stroke associated with high morbidity and mortality. Survival after aSAH has increased in recent decades due to early diagnosis, increasing rates of therapeutic aneurysm occlusion, and advanced care in the intensive care unit. Unfortunately, survivors still suffer from cognitive and functional impairments that significantly affect their quality of life. Many preclinical studies and clinical trials have been conducted from molecules to the real world, but few have resulted in significant improvement in outcomes. CONSCIOUS -1 is often recognized as a turning point for researchers and clinicians, showing that delayed cerebral ischemia (DCI) is a multifactorial consequence after aSAH, while the notion of early brain injury (EBI) has been strengthened since the early 2000s. The transition of research focus from DCI to EBI continues to evolve and is promising under the rapid development and introduction of novel experimental techniques, artificial intelligence, and improved study designs.
This Research Topic aims to attract cutting edge Original Research and Systematic Review, in addition to high quality narrative Reviews and meta-analyses in the area of basic and clinical studies on EBI/DCI after aSAH, contributing to a more comprehensive knowledge of these complications. We encourage submissions of laboratory experiments, as well as clinical studies describing novel mechanisms, diagnosis, and multidisciplinary treatment strategies for aSAH.
Topics of interest include:
- Potential etiology, pathogenesis, pathophysiological mechanisms for EBI/DCI following aSAH.
- Preclinical or clinical biomarkers for EBI/DCI/outcome after aSAH.
- Pilot studies and clinical trials in aSAH.
- Perioperative and intensive care multimodal monitoring and management after aSAH.
- Cognitive and functional outcomes after aSAH.