The interactions between reproductive systems and immune system have attracted increasing attention during the past decades. Accumulating evidence links immune disturbances to reproductive abnormalities such as impaired fertility, premature ovarian insufficiency, recurrent spontaneous abortions, gestational diabetes mellitus, pre-eclampsia, and preterm labor.
Reproductive immunology covers gametogenesis, fertilization, implantation of the embryos, invasion of the trophoblast cells, placentation, fetal organ development, maternal-fetal immune tolerance, and pathological pregnancy. However, the diverse roles of immune cells during these processes remain elusive. Understanding the immunological mechanisms in reproduction may shed light on developing new preventative and control strategies for infertility and pregnancy-related diseases.
In this Research Topic, we would like to collect manuscripts that address the role of immunity in the physiology and pathophysiology of fertility, pregnancy, pregnancy loss, and pregnancy-related diseases. Those which explore the immunological or inflammatory mechanisms during the process of reproduction would be preferred in the collection.
Original Research articles, Reviews, Mini-Reviews, and Meta-analysis are all welcomed in this special issue. The scope includes, but is not limited to, the following subtopics:
1) Physiology of immune response in fertility and pregnancy, including adoptive and innate immunity;
2) Aberrant immune responses in infertility, maternal-fetal immune tolerance, fetal development, and pregnancy-related conditions;
3) Autoimmune diseases in infertility and pregnancy loss;
4) Proinflammatory condition in gynecological endocrinopathies;
5) New notions for the comprehension of reproductive immunology from the lessons of other fields of immunology;
6) Anti-inflammatory therapy for infertility and pregnancy-related problems.
The interactions between reproductive systems and immune system have attracted increasing attention during the past decades. Accumulating evidence links immune disturbances to reproductive abnormalities such as impaired fertility, premature ovarian insufficiency, recurrent spontaneous abortions, gestational diabetes mellitus, pre-eclampsia, and preterm labor.
Reproductive immunology covers gametogenesis, fertilization, implantation of the embryos, invasion of the trophoblast cells, placentation, fetal organ development, maternal-fetal immune tolerance, and pathological pregnancy. However, the diverse roles of immune cells during these processes remain elusive. Understanding the immunological mechanisms in reproduction may shed light on developing new preventative and control strategies for infertility and pregnancy-related diseases.
In this Research Topic, we would like to collect manuscripts that address the role of immunity in the physiology and pathophysiology of fertility, pregnancy, pregnancy loss, and pregnancy-related diseases. Those which explore the immunological or inflammatory mechanisms during the process of reproduction would be preferred in the collection.
Original Research articles, Reviews, Mini-Reviews, and Meta-analysis are all welcomed in this special issue. The scope includes, but is not limited to, the following subtopics:
1) Physiology of immune response in fertility and pregnancy, including adoptive and innate immunity;
2) Aberrant immune responses in infertility, maternal-fetal immune tolerance, fetal development, and pregnancy-related conditions;
3) Autoimmune diseases in infertility and pregnancy loss;
4) Proinflammatory condition in gynecological endocrinopathies;
5) New notions for the comprehension of reproductive immunology from the lessons of other fields of immunology;
6) Anti-inflammatory therapy for infertility and pregnancy-related problems.