Spermatogonial stem cells differentiate and mature in testes and afterward in epididymides. Numerous studies have clarified the detailed structure and function of the male reproductive system and have shown that various biological controls, including genomics, epigenetics, and the neuroendocrine-immune system, regulate germ cell proliferation, differentiation, and maturation. However, a decrease in sperm count, sperm concentration, and sperm quality is a serious problem, although the causes are complex and remain unclear. In addition, fertility-sparing strategies for pre-and peripubertal male cancer patients (and hormonal side effects) need further studies and the accumulation of basic knowledge regarding the structure, function, and regulation of spermatogenesis is crucial to understanding and solving fertility problems encountered. To date, complete functional spermatogenesis (in vitro or in vivo) from human testicular tissue is not available and therefore cannot help a number of patients awaiting treatment for their infertility.
This Research Topic aims to compile the latest research on spermatogenesis in order to provide a state of the art of updated knowledge (Review, Mini-Review) as well as new scientific discoveries in the field (original research). Special attention will be dedicated to spermatogonial stem cells and somatic cells, essential for successful spermatogenesis and steroidogenesis. Finally, recent technologies to evaluate or recreate spermatogenesis will be studied.
The main goal of this Research Topic is to centralize in one place recent research on the topic of spermatogenesis in order to bring together research in a common topic.
The editors propose a progression of the volume from the stem cell to the functional spermatozoa, focusing on scientific advances, biological techniques around spermatogenesis (in vivo and in vitro), and clinical applications.
The main topics covered in this volume will be, but are not limited to:
• Spermatogenesis and steroidogenesis
• Maturity of Leydig & Sertoli cells evaluation: implication on spermatogenesis
• Hormonal regulation of spermatogenesis
• Environmental/lifestyle effects on spermatogenesis
• Preservation and restoration of male fertility
Spermatogonial stem cells differentiate and mature in testes and afterward in epididymides. Numerous studies have clarified the detailed structure and function of the male reproductive system and have shown that various biological controls, including genomics, epigenetics, and the neuroendocrine-immune system, regulate germ cell proliferation, differentiation, and maturation. However, a decrease in sperm count, sperm concentration, and sperm quality is a serious problem, although the causes are complex and remain unclear. In addition, fertility-sparing strategies for pre-and peripubertal male cancer patients (and hormonal side effects) need further studies and the accumulation of basic knowledge regarding the structure, function, and regulation of spermatogenesis is crucial to understanding and solving fertility problems encountered. To date, complete functional spermatogenesis (in vitro or in vivo) from human testicular tissue is not available and therefore cannot help a number of patients awaiting treatment for their infertility.
This Research Topic aims to compile the latest research on spermatogenesis in order to provide a state of the art of updated knowledge (Review, Mini-Review) as well as new scientific discoveries in the field (original research). Special attention will be dedicated to spermatogonial stem cells and somatic cells, essential for successful spermatogenesis and steroidogenesis. Finally, recent technologies to evaluate or recreate spermatogenesis will be studied.
The main goal of this Research Topic is to centralize in one place recent research on the topic of spermatogenesis in order to bring together research in a common topic.
The editors propose a progression of the volume from the stem cell to the functional spermatozoa, focusing on scientific advances, biological techniques around spermatogenesis (in vivo and in vitro), and clinical applications.
The main topics covered in this volume will be, but are not limited to:
• Spermatogenesis and steroidogenesis
• Maturity of Leydig & Sertoli cells evaluation: implication on spermatogenesis
• Hormonal regulation of spermatogenesis
• Environmental/lifestyle effects on spermatogenesis
• Preservation and restoration of male fertility
