About this Research Topic
Mitochondria are sensors and integrators of environmental cues in pathophysiological conditions. Mitochondria typically form a strict and hierarchical quality control system controlled by a dynamic network. They also communicate with other organelles, such as the endoplasmic reticulum and nucleus. Despite the advances in mitochondrial biology and improved methods to monitor mitochondrial defects, we are still far from fully understanding the events relating to the organelle that drive cardiovascular disorders. In addition, no effective therapeutics, to date, are available clinically to mitigate mitochondria-associated dysfunctions. In this endeavor, studies are needed to elucidate different biological mechanisms linking mitochondria with CVDs, develop new tools for mitochondrial research, and explore new targets for mitochondria-based therapies.
In this research topic, we would like to collate articles that will extend our understanding of the molecular bases, methods, and therapeutic approaches involved in mitochondria-related CVDs. Therefore, we welcome Original Research, Methods, Review, and Mini-Review articles that cover, but are not limited to, the following topics:
• Genetic defects of mitochondria in cardiovascular diseases
• Biological bases of mitochondria involved in the pathogenesis of cardiovascular diseases, including myocardial infarction, cardiomyopathy, heart failure, hypertension, atherosclerosis, and other vascular diseases
• Novel function and mechanisms of mitochondria-related metabolism, calcium flux, mitochondrial dynamics, apoptosis, and ferroptosis
• Mitochondrial targeting (MTA) therapy
• Mitochondrial alterations at the genetic, protein, and metabolite levels under extreme environment
Keywords: Mitochondria, Metabolism, Cell death, Inflammatory responses and oxidative stress, Organelles crosstalk, mtDNA, Cardiovascular diseases, Mechanisms, Therapy
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.