About this Research Topic

Manuscript Submission Deadline 15 October 2022

Critically ill patients, particularly those admitted for severe sepsis/septic shock or postoperatively, are prone to clinically significant fluid accumulation (fluid overload) as they often receive large volumes of fluids during their stay and suffer from substantial fluid sequestration due to capillary leak. The association of positive fluid balance, respectively fluid overload and mortality in critically ill has been shown in several studies and consecutively the awareness of the detrimental effects of fluid overload has grown. In addition, fluid overload has an impact on other patient-centred outcomes, such as risk of acute kidney failure, prolonged mechanical ventilation and prolonged ICU stay. Thus, fluid overload became a hot topic in ICU in the recent years and studies evaluating enhanced fluid strategies, the assessment of fluid overload and translational aspects of fluid overload in critically ill have grown. However, the ideal fluid strategy with impact on survival or critically ill patients has not been found yet. In addition, individualised patient-centred approaches for the assessment and management of fluid overload, as well as factors for early detection of patients at risk are warranted.

The goal of this research topic is to gain more insight into prospects of new fluid strategies for the critically ill in general or particular subgroups, new technologies for the detection of fluid overload or fluid responsiveness, de-resuscitation strategies, and novel biomarkers to guide fluid management.

We welcome original articles, reviews and case series addressing the conundrum of fluid overload in the critically ill.

Keywords: fluid overload, critical care, capillary leak, resuscitation, de-resuscitation, fluid restriction, diuretics


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Critically ill patients, particularly those admitted for severe sepsis/septic shock or postoperatively, are prone to clinically significant fluid accumulation (fluid overload) as they often receive large volumes of fluids during their stay and suffer from substantial fluid sequestration due to capillary leak. The association of positive fluid balance, respectively fluid overload and mortality in critically ill has been shown in several studies and consecutively the awareness of the detrimental effects of fluid overload has grown. In addition, fluid overload has an impact on other patient-centred outcomes, such as risk of acute kidney failure, prolonged mechanical ventilation and prolonged ICU stay. Thus, fluid overload became a hot topic in ICU in the recent years and studies evaluating enhanced fluid strategies, the assessment of fluid overload and translational aspects of fluid overload in critically ill have grown. However, the ideal fluid strategy with impact on survival or critically ill patients has not been found yet. In addition, individualised patient-centred approaches for the assessment and management of fluid overload, as well as factors for early detection of patients at risk are warranted.

The goal of this research topic is to gain more insight into prospects of new fluid strategies for the critically ill in general or particular subgroups, new technologies for the detection of fluid overload or fluid responsiveness, de-resuscitation strategies, and novel biomarkers to guide fluid management.

We welcome original articles, reviews and case series addressing the conundrum of fluid overload in the critically ill.

Keywords: fluid overload, critical care, capillary leak, resuscitation, de-resuscitation, fluid restriction, diuretics


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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