Clinical and Genetic Determinants of Diabetes and Complications

174.8K

views

249

authors

31

articles

Clinical and Genetic Determinants of Diabetes and Complications

174.8K

views

249

authors

31

articles

Editorial

04 July 2023

Editorial: Clinical and genetic determinants of diabetes and complications

Sen Li

,

Maurizio Delvecchio

,

Kunka Mohanram Ramkumar

,

Xiaowen Mao

, 1 more and

Shuzhen Guo

1,760 views

1 citations

Editors

6

Beijing University of Chinese Medicine

Maurizio Delvecchio

University of L'Aquila

University of Macau

Beijing University of Chinese Medicine

AFFILIATED HOSPITAL OF SHANDONG SECOND MEDICAL UNIVERSITY

Ramkumar Kunka Mohanram

SRM Institute of Science and Technology

Impact

Fetching...

About

Diabetes Mellitus (DM) remains one of the leading causes of death around the world, which leads to a heavy global burden on public health. As predicted by International Diabetes Federation, a 50% increase in the number of patients with DM will be reached by 2030 compared to 366 million in 2011. DM has multiple complications that cause the injury of several organs such as heart and kidneys, leading to a reduction in quality of life and a higher premature mortality rate. For example, diabetic patients have two-fold increased risk for cardiovascular mortality. The pathogenesis of DM is multifactorial, and several clinical risk factors, such as being overweight or obese, have been proposed. But the contributions of several other putative factors on the pathogenesis of DM are still inconclusive. At genetic level, a family history of DM increases DM risk, and more than 500 genetic loci have been found to be associated with DM. However, the genetic determinants of DM complications are less understood. Most importantly, we are far from understanding the complex interaction effects of clinical and genetic factors on DM risk.

In this Research Topic, we hope to create a forum for the new insights into understanding the role of clinical and genetic risk factors as well as their potential interaction in the pathogenesis of diabetes and its complications. We welcome submissions of Original research articles, Review articles, Opinions and Perspectives, in the subtopics of the following, but not limited to:

• Clinical risk factors that contribute to the pathogenesis of diabetes
• Clinical risk factors affecting the development of complications in diabetic patients
• Genetic basis of diabetes and its complications
• The role of interaction between clinical and genetic risk factors in diabetes

Diabetes Mellitus (DM) remains one of the leading causes of death around the world, which leads to a heavy global burden on public health. As predicted by International Diabetes Federation, a 50% increase in the number of patients with DM will be reached by 2030 compared to 366 million in 2011. DM has multiple complications that cause the injury of several organs such as heart and kidneys, leading to a reduction in quality of life and a higher premature mortality rate. For example, diabetic patients have two-fold increased risk for cardiovascular mortality. The pathogenesis of DM is multifactorial, and several clinical risk factors, such as being overweight or obese, have been proposed. But the contributions of several other putative factors on the pathogenesis of DM are still inconclusive. At genetic level, a family history of DM increases DM risk, and more than 500 genetic loci have been found to be associated with DM. However, the genetic determinants of DM complications are less understood. Most importantly, we are far from understanding the complex interaction effects of clinical and genetic factors on DM risk.

In this Research Topic, we hope to create a forum for the new insights into understanding the role of clinical and genetic risk factors as well as their potential interaction in the pathogenesis of diabetes and its complications. We welcome submissions of Original research articles, Review articles, Opinions and Perspectives, in the subtopics of the following, but not limited to:

• Clinical risk factors that contribute to the pathogenesis of diabetes
• Clinical risk factors affecting the development of complications in diabetic patients
• Genetic basis of diabetes and its complications
• The role of interaction between clinical and genetic risk factors in diabetes

Download ebook

Share

Editors

Beijing University of Chinese Medicine

Maurizio Delvecchio

University of L'Aquila

University of Macau

Beijing University of Chinese Medicine

AFFILIATED HOSPITAL OF SHANDONG SECOND MEDICAL UNIVERSITY

Ramkumar Kunka Mohanram

SRM Institute of Science and Technology

Impact

174,795 Total views

112,994 Article views

58,582 Article downloads

3,219 Topic views

Published In

Journal Thumbnail

Frontiers in Endocrinology

Clinical Diabetes

Journal Thumbnail

Frontiers in Public Health

Clinical Diabetes

Journal Thumbnail

Frontiers in Neuroscience

Clinical Diabetes

Journal Thumbnail

Frontiers in Nutrition

Clinical Diabetes

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Suggest a topic