About this Research Topic

Abstract Submission Deadline 04 October 2022
Manuscript Submission Deadline 03 December 2022

Normal sperm function, including motility, capacitation, hyperactivation, acrosome reaction, chemotaxis, thermotaxis, and rheotaxis, is vital for natural fertilization. The sperm function is involved in many signal pathways and plays an important role in successful fertilization. Various methods have been developed to assess different sperm functions, and some biomarkers have been regarded as essential for male reproduction. These will be potentially translated into the evaluation and diagnosis of male reproduction in a clinical background. Along with the developments of in vitro fertilization (IVF), various novel methods and techniques for sperm selection have been developed to improve sperm quality, and it should be fully reckoned that the sperm with malfunctions in vivo can be easily screened in different positions of the female reproductive tract. Furthermore, sperm selection via assistant reproductive technology (ART) is closely associated with clinical outcomes and the health of offspring. Therefore, it's essential to catch up with research development in sperm function and selection.

This research topic aims to provide novel insights into sperm function and sperm selection. It will discuss new findings of basic research on sperm functions and ongoing developments in sperm selection. The novel translation bridging the gap between basic research and clinical application is also welcome, especially new applications and their clinical outcomes in the context of ART.

This research topic aims at discussing the following scientific questions, including but not limited to:
• New genes, different classes of RNAs, proteins, lipids, metabolites, and their signal pathway involving sperm function;
• Post-translational modifications of proteins and the signaling pathway involving sperm function, including phosphorylation, ubiquitination, glycosylation, acetylation, palmitoylation, and others;
• New findings on how extracellular vesicles (exosomes) in the reproductive tract regulate sperm function;
• New biomarkers on sperm function associated with male infertility diagnosis or clinical ART outcomes;
• New developing methods for sperm selection or evaluation of sperm function;
• New applications on sperm selection and preparation in clinical ART lab;
• New findings on the correlation between sperm function and male infertility diagnosis or clinical outcomes in ART;
• New findings on the correlation between sperm selection and the health of offspring via ART;
To avoid overlapping with other Research Topics in Frontiers in Endocrinology, spermatogenesis and the stem cells that are involved in spermatozoa will be out of the scope of this topic.

Keywords: Sperm, sperm function, sperm motility, acrosome reaction, sperm selection, IVF, chemotaxis, Spermatozoa, Hyperactivation, Thermotaxis, Rheotaxis, Asthenospermia, Male infertility, Fertilization, in vitro Fertilization, Sperm preparation, Assisted reproductive technology, ART, capacitation, sperm-egg fusion


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Normal sperm function, including motility, capacitation, hyperactivation, acrosome reaction, chemotaxis, thermotaxis, and rheotaxis, is vital for natural fertilization. The sperm function is involved in many signal pathways and plays an important role in successful fertilization. Various methods have been developed to assess different sperm functions, and some biomarkers have been regarded as essential for male reproduction. These will be potentially translated into the evaluation and diagnosis of male reproduction in a clinical background. Along with the developments of in vitro fertilization (IVF), various novel methods and techniques for sperm selection have been developed to improve sperm quality, and it should be fully reckoned that the sperm with malfunctions in vivo can be easily screened in different positions of the female reproductive tract. Furthermore, sperm selection via assistant reproductive technology (ART) is closely associated with clinical outcomes and the health of offspring. Therefore, it's essential to catch up with research development in sperm function and selection.

This research topic aims to provide novel insights into sperm function and sperm selection. It will discuss new findings of basic research on sperm functions and ongoing developments in sperm selection. The novel translation bridging the gap between basic research and clinical application is also welcome, especially new applications and their clinical outcomes in the context of ART.

This research topic aims at discussing the following scientific questions, including but not limited to:
• New genes, different classes of RNAs, proteins, lipids, metabolites, and their signal pathway involving sperm function;
• Post-translational modifications of proteins and the signaling pathway involving sperm function, including phosphorylation, ubiquitination, glycosylation, acetylation, palmitoylation, and others;
• New findings on how extracellular vesicles (exosomes) in the reproductive tract regulate sperm function;
• New biomarkers on sperm function associated with male infertility diagnosis or clinical ART outcomes;
• New developing methods for sperm selection or evaluation of sperm function;
• New applications on sperm selection and preparation in clinical ART lab;
• New findings on the correlation between sperm function and male infertility diagnosis or clinical outcomes in ART;
• New findings on the correlation between sperm selection and the health of offspring via ART;
To avoid overlapping with other Research Topics in Frontiers in Endocrinology, spermatogenesis and the stem cells that are involved in spermatozoa will be out of the scope of this topic.

Keywords: Sperm, sperm function, sperm motility, acrosome reaction, sperm selection, IVF, chemotaxis, Spermatozoa, Hyperactivation, Thermotaxis, Rheotaxis, Asthenospermia, Male infertility, Fertilization, in vitro Fertilization, Sperm preparation, Assisted reproductive technology, ART, capacitation, sperm-egg fusion


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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