About this Research Topic
In this Research Topic we will explore the synergistic effects and mechanisms between DNA damage induction and inflammatory response under a variety of cellular stresses like radiations, replication stress, environmental chemicals etc. Priority will be given to studies following a holistic approach and at the organism level from plants, flies, worms to mouse and humans. We believe this to be a genuine example of System Biology application in life.
Several lines of evidence suggest that DNA-damage can cause immune reaction and inflammation, and is linked to cancer development and other pathologies. On the other hand, it is generally accepted that chronic inflammation can cause DNA persistent damage.
In this Research Topic we welcome all contributions relative to the above field and groups working in the all of the above areas and model organisms linking DNA damage, inflammatory and innate immune response and a variety of systemic effects associated with the above phenomena. Special interest is given to the role of DNA damage response (DDR) genes and their link with inflammatory proteins, underlying molecular mechanisms justifying the system-level analysis of systemic action, computational and bioinformatic approaches for better description of real biological systems and integration of current empirical or theoretical knowledge.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.