Macrophages are key regulators of immunity and tissue homeostasis and dysregulation of their activities contributes to a wide range of human diseases. The local environmental context plays a crucial role in determining the function and phenotype of macrophages through the regulation of gene transcription. Stimulus-activated transcription factors as well as other transcriptional regulators like epigenetic enzymes, chromatin remodeling factors, co-activators, or co-repressors regulate the activity of enhancers and promoters. They thereby determine the transcriptional output and regulate cellular responses and the phenotype of the macrophage.
In this research topic, we would like to further our knowledge of transcriptional mechanisms that can regulate macrophage function: in vitro and in vivo, in health and disease. We hope this will lead to a better understanding of how the macrophage's phenotype is regulated and can lead to the identification of novel regulators of (disease- or signal-activated) gene transcription programs in macrophages. In the future, this may lead to novel intervention strategies targeting macrophage transcriptional programs in disease.
For this special issue on the transcriptional regulation of macrophage function, we are looking for original research or review articles that discuss transcriptional mechanisms that can regulate macrophage function: in vitro or in vivo, in health or disease. This can include manuscripts that discuss: specific gene programs, enhancers and/or transcription factors that are or can be activated in macrophages; the epigenetic regulation of gene expression or investigation of signaling pathways that can be activated by environmental stimuli, like cytokines or danger/pathogen-associated molecular patterns, in macrophages; or the influence of disease-associated signals or genetic variants that can influence macrophage function.
Macrophages are key regulators of immunity and tissue homeostasis and dysregulation of their activities contributes to a wide range of human diseases. The local environmental context plays a crucial role in determining the function and phenotype of macrophages through the regulation of gene transcription. Stimulus-activated transcription factors as well as other transcriptional regulators like epigenetic enzymes, chromatin remodeling factors, co-activators, or co-repressors regulate the activity of enhancers and promoters. They thereby determine the transcriptional output and regulate cellular responses and the phenotype of the macrophage.
In this research topic, we would like to further our knowledge of transcriptional mechanisms that can regulate macrophage function: in vitro and in vivo, in health and disease. We hope this will lead to a better understanding of how the macrophage's phenotype is regulated and can lead to the identification of novel regulators of (disease- or signal-activated) gene transcription programs in macrophages. In the future, this may lead to novel intervention strategies targeting macrophage transcriptional programs in disease.
For this special issue on the transcriptional regulation of macrophage function, we are looking for original research or review articles that discuss transcriptional mechanisms that can regulate macrophage function: in vitro or in vivo, in health or disease. This can include manuscripts that discuss: specific gene programs, enhancers and/or transcription factors that are or can be activated in macrophages; the epigenetic regulation of gene expression or investigation of signaling pathways that can be activated by environmental stimuli, like cytokines or danger/pathogen-associated molecular patterns, in macrophages; or the influence of disease-associated signals or genetic variants that can influence macrophage function.
