About this Research Topic

Abstract Submission Deadline 06 December 2022
Manuscript Submission Deadline 08 March 2023

Exosomes offer diverse opportunities for research and treatment in endocrine and metabolic disorders due to their tendency to crosstalk between cells and organs. Studies have demonstrated the role of exosomes in osteogenesis and adipogenesis mediated by miRNAs. In addition, exosomes of skeletal muscles regulate the metabolic and physiological control of lifestyle disorders, physical fitness, and endocrine abnormalities. Similarly, exosomes have been claimed to exhibit biomarker and regulator characteristics in metabolic syndrome.

Because these membrane vesicles are rich in biomolecules such as proteins, peptides, lipids, and nucleic acids, they can be used for diagnostic and therapeutic purposes in endocrine and metabolic diseases. For example, adiponectin-stimulated exosomes promote cell homeostasis and maintain the health of endothelial cells, while exosomes derived from mesenchymal stromal cells exhibit the potential for immunomodulation and therefore can be effectively used for the treatment of type 1 diabetes mellitus (T1DM) due to their tolerogenic potential. These vesicles have the tendency to alter using widely available approaches including freeze-thaw, electroporation, genetic engineering, and many more that further help in the targeted delivery of important drugs/molecules within the endocrine organs as therapeutic approaches.

Because of their non-toxic behavior as well as increased bioavailability and bio-distribution, exosomes are a preferred choice of drug delivery agent. Because of their non-immunogenicity and rapid extraction, exosomes associated with miRNAs can now be used as diagnostic and therapeutic agents for metabolic disorders. A metabolomics approach using exosome-derived biomolecules can also be helpful in the diagnosis of endocrine and metabolic diseases.

This Research Topic welcomes original research articles, reviews, mini-reviews, and commentaries. Topics of interest include but are not limited to:

• Exosome isolation, purification, and scaling-up methods for investigating their clinical

potential

• Biotechnology-based approaches for the modification of exosomes

• Imaging and screening modalities of exosomes in endocrine and metabolic diseases

• Molecular mechanisms, key signaling pathways, and novel therapeutics of exosome mediated approaches in the treatment of endocrine and metabolic diseases

• Targeted drug delivery using exosomes for the treatment of endocrine and metabolic

diseases

• Clinical trials concerning endocrine and metabolic outcomes with exosomes

Keywords: Exosomes, Endocrine disease, Metabolic Disease, Therapeutics, Diagnostics


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Exosomes offer diverse opportunities for research and treatment in endocrine and metabolic disorders due to their tendency to crosstalk between cells and organs. Studies have demonstrated the role of exosomes in osteogenesis and adipogenesis mediated by miRNAs. In addition, exosomes of skeletal muscles regulate the metabolic and physiological control of lifestyle disorders, physical fitness, and endocrine abnormalities. Similarly, exosomes have been claimed to exhibit biomarker and regulator characteristics in metabolic syndrome.

Because these membrane vesicles are rich in biomolecules such as proteins, peptides, lipids, and nucleic acids, they can be used for diagnostic and therapeutic purposes in endocrine and metabolic diseases. For example, adiponectin-stimulated exosomes promote cell homeostasis and maintain the health of endothelial cells, while exosomes derived from mesenchymal stromal cells exhibit the potential for immunomodulation and therefore can be effectively used for the treatment of type 1 diabetes mellitus (T1DM) due to their tolerogenic potential. These vesicles have the tendency to alter using widely available approaches including freeze-thaw, electroporation, genetic engineering, and many more that further help in the targeted delivery of important drugs/molecules within the endocrine organs as therapeutic approaches.

Because of their non-toxic behavior as well as increased bioavailability and bio-distribution, exosomes are a preferred choice of drug delivery agent. Because of their non-immunogenicity and rapid extraction, exosomes associated with miRNAs can now be used as diagnostic and therapeutic agents for metabolic disorders. A metabolomics approach using exosome-derived biomolecules can also be helpful in the diagnosis of endocrine and metabolic diseases.

This Research Topic welcomes original research articles, reviews, mini-reviews, and commentaries. Topics of interest include but are not limited to:

• Exosome isolation, purification, and scaling-up methods for investigating their clinical

potential

• Biotechnology-based approaches for the modification of exosomes

• Imaging and screening modalities of exosomes in endocrine and metabolic diseases

• Molecular mechanisms, key signaling pathways, and novel therapeutics of exosome mediated approaches in the treatment of endocrine and metabolic diseases

• Targeted drug delivery using exosomes for the treatment of endocrine and metabolic

diseases

• Clinical trials concerning endocrine and metabolic outcomes with exosomes

Keywords: Exosomes, Endocrine disease, Metabolic Disease, Therapeutics, Diagnostics


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Topic Editors

Loading..

Topic Coordinators

Loading..

articles

Sort by:

Loading..

authors

Loading..

views

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..

Share on

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.