Sarcopenia is a multifactorial complex geriatric syndrome characterized by a progressive and generalized loss of skeletal muscle mass and strength. It is a key driver of frailty, disability, and mortality in older adults. During the pathological process of sarcopenia, several signaling pathways and physiological changes lead to increased proteolysis, reduced synthesis of muscle fibers, mitochondrial dysfunction, accumulation of intra-muscular fat and chronic inflammation, among others. However, the molecular and physiological driving mechanisms under these pathological processes are still poorly defined.
Variables such as genetic factors, molecular aging, and hormonal changes are known contributors to sarcopenia but the heterogeneity of clinical phenotypes, the complex pathophysiology and the lack of standardized biomarkers complicate the development of efficient treatments for sarcopenia. More insights into the genetics and the genomics of sarcopenia, the molecular driving pathways involved, and the specific role of hormones are needed to clarify sarcopenia pathogenesis and to develop efficient molecular diagnostic and therapeutic approaches. The aim of this Research Topic is to address the novel findings on the molecular and physiological mechanisms contributing to sarcopenia, the molecular diagnostic procedures, and the pharmacological therapeutic approaches for this condition. This article collection aims to gather basic researchers working in the muscle aging field in either humans or pre-clinical models and clinician experts in sarcopenia management to increase our knowledge of the molecular pathophysiology of sarcopenia as well as our understanding of novel molecular diagnostic and therapeutic procedures.
Researchers are encouraged to submit original research articles, pharmacological intervention studies, reviews, mini-reviews, perspectives, short communications as well as theoretical papers, opinions, and methods relevant to this article collection that will cover topics such as (but not limited to):
- genetic and molecular mechanisms of neuromuscular and skeletal muscle aging
- role of hormones in sarcopenia development, prognosis, and therapy
- molecular and physiological mechanisms of sarcopenic obesity and other sarcopenia-related conditions
- new molecular and physiological findings for sarcopenia prevention, diagnosis, and treatment
Sarcopenia is a multifactorial complex geriatric syndrome characterized by a progressive and generalized loss of skeletal muscle mass and strength. It is a key driver of frailty, disability, and mortality in older adults. During the pathological process of sarcopenia, several signaling pathways and physiological changes lead to increased proteolysis, reduced synthesis of muscle fibers, mitochondrial dysfunction, accumulation of intra-muscular fat and chronic inflammation, among others. However, the molecular and physiological driving mechanisms under these pathological processes are still poorly defined.
Variables such as genetic factors, molecular aging, and hormonal changes are known contributors to sarcopenia but the heterogeneity of clinical phenotypes, the complex pathophysiology and the lack of standardized biomarkers complicate the development of efficient treatments for sarcopenia. More insights into the genetics and the genomics of sarcopenia, the molecular driving pathways involved, and the specific role of hormones are needed to clarify sarcopenia pathogenesis and to develop efficient molecular diagnostic and therapeutic approaches. The aim of this Research Topic is to address the novel findings on the molecular and physiological mechanisms contributing to sarcopenia, the molecular diagnostic procedures, and the pharmacological therapeutic approaches for this condition. This article collection aims to gather basic researchers working in the muscle aging field in either humans or pre-clinical models and clinician experts in sarcopenia management to increase our knowledge of the molecular pathophysiology of sarcopenia as well as our understanding of novel molecular diagnostic and therapeutic procedures.
Researchers are encouraged to submit original research articles, pharmacological intervention studies, reviews, mini-reviews, perspectives, short communications as well as theoretical papers, opinions, and methods relevant to this article collection that will cover topics such as (but not limited to):
- genetic and molecular mechanisms of neuromuscular and skeletal muscle aging
- role of hormones in sarcopenia development, prognosis, and therapy
- molecular and physiological mechanisms of sarcopenic obesity and other sarcopenia-related conditions
- new molecular and physiological findings for sarcopenia prevention, diagnosis, and treatment
