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The brain contains extensive neural circuits, spanning a number of specialized brain structures that control and regulate endocrine, autonomic and inflammatory outputs. These neuroendocrine, autonomic and neuroinflammatory brain circuits can be activated by external and internal physiological stressors that ...

The brain contains extensive neural circuits, spanning a number of specialized brain structures that control and regulate endocrine, autonomic and inflammatory outputs. These neuroendocrine, autonomic and neuroinflammatory brain circuits can be activated by external and internal physiological stressors that are implicated in cardiometabolic function and disease.

An increasing number of research indicates that dysfunction of these circuits may lead to the development of cardiometabolic diseases. While the circuits are well characterized, our knowledge is still limited about the interaction between them in cardiometabolic diseases.

The goal of this Research Topic is to provide an updated understanding of the interaction between the neural circuits that regulate neuroendocrine, autonomic and neuroinflammatory processes and the implication of these circuits in cardiometabolic diseases. Furthermore, we aim to summarize the responses of these neural circuits to internal or external stressors involved in cardiometabolic diseases. In light of this, the scope of the present Frontiers Research Topic is broad and it aims to provide a comprehensive insight into this exciting research area.

Articles ranging from cell-to-cell communication, basic sciences investigation (in vitro and in vivo) to translational and clinical studies are welcome. Articles that cover current therapies are also of interest to this collection.

We would like to extend special thanks to the coordinator of this Research Topic Dr. Khalid Elsaafien, who is currently affiliated with the University of Florida in Gainesville, USA. His research interests include neural circuits that control and regulate blood pressure.

Keywords: The Neuroendocrine, Autonomic and Neuroinflammatory Stress Axes in Cardiometabolic Disease


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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