Angiotensin-converting enzyme (ACE) is best known for its effects on blood pressure since it produces the potent vasoconstrictor, angiotensin II. ACE also plays multiple roles in the physiological processes, such as regulating normal renal development, male reproductive ability, hematopoiesis, as well as pathophysiological processes, including inflammatory diseases. ACE inhibitors (ACEi) are widely used in treating hypertension and heart failure. However, recent studies show that a lack of ACE would potentially damage neutrophil- and/or macrophage-immune functions during bacterial infection and tumor progression. Meanwhile, myeloid cells with increased ACE could enhance immune response and metabolic functions. These studies suggest that ACE activity in myeloid cells plays a pivotal role in regulating the immune response, especially in bacterial and tumor elimination. However, little is known about the effect of ACE inhibition on myeloid cells during acute and chronic inflammation in patients treated with ACEi (e.g., patients with hypertension, heart failure, and diabetes).
This Research Topic welcomes basic, translational, computational, and applied research on the ACE and myeloid cell functions during the immune response.
Potential areas of interest may include, but are not limited to:
1. Effect of ACE on myeloid cell metabolic functions,
2. The connection of ACE and ACE2 on myeloid immune functions,
3. ACE-related myeloid cells molecular mechanism,
4. Substrates and productions of ACE in regulating immune response,
5. Function study of myeloid ACE on disease onset and progression,
6. Long-term effects of ACE inhibitors on the immune system,
7. Myeloid cells' immune function in hypertension.
We welcome the submission of different article types to this collection, especially reviews, mini-reviews, original research papers, and brief research reports.
Angiotensin-converting enzyme (ACE) is best known for its effects on blood pressure since it produces the potent vasoconstrictor, angiotensin II. ACE also plays multiple roles in the physiological processes, such as regulating normal renal development, male reproductive ability, hematopoiesis, as well as pathophysiological processes, including inflammatory diseases. ACE inhibitors (ACEi) are widely used in treating hypertension and heart failure. However, recent studies show that a lack of ACE would potentially damage neutrophil- and/or macrophage-immune functions during bacterial infection and tumor progression. Meanwhile, myeloid cells with increased ACE could enhance immune response and metabolic functions. These studies suggest that ACE activity in myeloid cells plays a pivotal role in regulating the immune response, especially in bacterial and tumor elimination. However, little is known about the effect of ACE inhibition on myeloid cells during acute and chronic inflammation in patients treated with ACEi (e.g., patients with hypertension, heart failure, and diabetes).
This Research Topic welcomes basic, translational, computational, and applied research on the ACE and myeloid cell functions during the immune response.
Potential areas of interest may include, but are not limited to:
1. Effect of ACE on myeloid cell metabolic functions,
2. The connection of ACE and ACE2 on myeloid immune functions,
3. ACE-related myeloid cells molecular mechanism,
4. Substrates and productions of ACE in regulating immune response,
5. Function study of myeloid ACE on disease onset and progression,
6. Long-term effects of ACE inhibitors on the immune system,
7. Myeloid cells' immune function in hypertension.
We welcome the submission of different article types to this collection, especially reviews, mini-reviews, original research papers, and brief research reports.