With advances in techniques such as genome and exome-wide sequencing, novel mutations associated with human diseases have been identified. Characterization of the relationship between DNA sequence variants (genotype) and the susceptibility to organ failure is essential for understanding the genetics of disease traits. To recapitulate the phenotypes of human genetic diseases, cell or animal models have been generated, enabling the interrogation of the underlying mechanisms of disease pathogenesis and organ failure. In addition, genome editing tools, particularly CRISPR/Cas9, adeno-associated virus-mediated in vivo gene delivery, as well as stem cell-based approaches, have been implemented to treat genetic diseases or induce organ regeneration.
The Research Topic aims to create a collection of articles that are related to the genetic basis of organ failure and regeneration. We welcome Original Research, Methods, Case Reports, and Review papers focused on implementing animal or cell models to study the mechanism, diagnosis, or treatment of human genetic diseases. Potential areas of interest include, but are not limited to:
- Animal or cell models of human diseases
- Genetic basis of organ dysfunction or failure
- Molecular diagnostics for human genetic diseases
- Strategies to correct genetic variants specifically adapted to the study of organ failure and regeneration
- Mechanisms of organ regeneration
- New technologies for inducing tissue repair
- Clinical research on organ dysfunction and regeneration
Keywords: Genetic model, human diseases, genetic variants, organ failure, tissue dysfunction, regeneration
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
With advances in techniques such as genome and exome-wide sequencing, novel mutations associated with human diseases have been identified. Characterization of the relationship between DNA sequence variants (genotype) and the susceptibility to organ failure is essential for understanding the genetics of disease traits. To recapitulate the phenotypes of human genetic diseases, cell or animal models have been generated, enabling the interrogation of the underlying mechanisms of disease pathogenesis and organ failure. In addition, genome editing tools, particularly CRISPR/Cas9, adeno-associated virus-mediated in vivo gene delivery, as well as stem cell-based approaches, have been implemented to treat genetic diseases or induce organ regeneration.
The Research Topic aims to create a collection of articles that are related to the genetic basis of organ failure and regeneration. We welcome Original Research, Methods, Case Reports, and Review papers focused on implementing animal or cell models to study the mechanism, diagnosis, or treatment of human genetic diseases. Potential areas of interest include, but are not limited to:
- Animal or cell models of human diseases
- Genetic basis of organ dysfunction or failure
- Molecular diagnostics for human genetic diseases
- Strategies to correct genetic variants specifically adapted to the study of organ failure and regeneration
- Mechanisms of organ regeneration
- New technologies for inducing tissue repair
- Clinical research on organ dysfunction and regeneration
Keywords: Genetic model, human diseases, genetic variants, organ failure, tissue dysfunction, regeneration
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
