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About this Research Topic

Manuscript Submission Deadline 30 April 2023

Lung and heart share the task of providing oxygen to the body and remove carbon dioxide. Both organs share proximity in the thorax, where their function is linked mechanically in addition to neurohumoral interplay. Diseases of heart or lung will inevitably affect the other. In critical care medicine, heart-lung interactions are a core topic at the bedside. They are observed in several situations of the ventilated patients and are often used to diagnose cardiovascular or pulmonary aberrations or to monitor and even predict responses to treatment, in particular right ventricular failure and volume responsiveness. Echocardiography has recently provided new insights besides classical right heart catheterization.

This Research Topic aims to assemble research studies contributing to the pathophysiological understanding of mechanisms of the various heart-lung interactions of the critically ill. Recent developments in cardiopulmonary critical care were coined by the widespread use of mechanical circulatory or pulmonary support. Heart-lung interactions in this context are largely unexplored and of particular interest. We would like to broaden the scope from classic mechanical interactions to include effects of and on gas exchange and pulmonary perfusion, respiratory muscle function and diastolic cardiac function, with all mutual dependencies.

We welcome basic science and clinical original research articles or reviews on all different aspects of heart-lung interactions in the critically ill with a broad scope. Of particular interest are contributions that address:

• Effects of extracorporeal circulatory or pulmonary support on heart-lung interactions
• Effects of gas exchange and the role of the V/Q relationship for heart-lung interactions
• Diagnostic procedures based on heart-lung interactions for prediction of treatment response
• Modern echocardiographic techniques like speckle-tracking in the context of heart-lung interactions
• Modern imaging techniques like electrical impedance tomography, magnetic resonance imaging or double energy computed tomography
• Neurohumoral interactions and effects of sedation
• Diastolic cardiac function during mechanical ventilation

Topic Editor David Berger's unit has a research and development contract with Edward Lifesciences. Topic Editor Antoine Vieillard-Barron declares no competing interests with regard to the Research Topic subject.

Keywords: Heart-lung Interactions, Right Ventricular Function, Mechanical Ventilation, Extracorporeal Support


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Lung and heart share the task of providing oxygen to the body and remove carbon dioxide. Both organs share proximity in the thorax, where their function is linked mechanically in addition to neurohumoral interplay. Diseases of heart or lung will inevitably affect the other. In critical care medicine, heart-lung interactions are a core topic at the bedside. They are observed in several situations of the ventilated patients and are often used to diagnose cardiovascular or pulmonary aberrations or to monitor and even predict responses to treatment, in particular right ventricular failure and volume responsiveness. Echocardiography has recently provided new insights besides classical right heart catheterization.

This Research Topic aims to assemble research studies contributing to the pathophysiological understanding of mechanisms of the various heart-lung interactions of the critically ill. Recent developments in cardiopulmonary critical care were coined by the widespread use of mechanical circulatory or pulmonary support. Heart-lung interactions in this context are largely unexplored and of particular interest. We would like to broaden the scope from classic mechanical interactions to include effects of and on gas exchange and pulmonary perfusion, respiratory muscle function and diastolic cardiac function, with all mutual dependencies.

We welcome basic science and clinical original research articles or reviews on all different aspects of heart-lung interactions in the critically ill with a broad scope. Of particular interest are contributions that address:

• Effects of extracorporeal circulatory or pulmonary support on heart-lung interactions
• Effects of gas exchange and the role of the V/Q relationship for heart-lung interactions
• Diagnostic procedures based on heart-lung interactions for prediction of treatment response
• Modern echocardiographic techniques like speckle-tracking in the context of heart-lung interactions
• Modern imaging techniques like electrical impedance tomography, magnetic resonance imaging or double energy computed tomography
• Neurohumoral interactions and effects of sedation
• Diastolic cardiac function during mechanical ventilation

Topic Editor David Berger's unit has a research and development contract with Edward Lifesciences. Topic Editor Antoine Vieillard-Barron declares no competing interests with regard to the Research Topic subject.

Keywords: Heart-lung Interactions, Right Ventricular Function, Mechanical Ventilation, Extracorporeal Support


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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