About this Research Topic
The Neuroscience portfolio at Frontiers is launching Research Topics to promote international scientific awareness of mental health disorders. Over the past few decades, major progress has been made toward addressing inequalities for people with mental health Disorders, which have been exacerbated by the COVID-19 pandemic with disproportionate increases in loneliness, disruptions to routines, and services and support systems.
This Research Topic article collection will focus on neuroscience research that can inform solutions for creating a culture of awareness, understanding, and solidarity, with this Topic focusing on the progress and challenges still faced in understanding the Synaptic Neuroscience of Fear Conditioning.
The Research Topic solicits brief, forward-looking contributions from researchers around the globe that describe the state of the art, outline recent developments and major accomplishments that have been achieved and what needs to occur to move the field forward. Authors are encouraged to identify the greatest challenges in their sub-disciplines, and to formulate how to begin to address those challenges.
This special edition Research Topic aims to shed light on the progress made in the past decade in the field of Synaptic Neuroscience and Fear Conditioning and on the challenges ahead while providing a thorough overview of the state of the art in Synaptic Neuroscience. This article collection is intended to inspire, inform and provide direction and guidance to researchers in the field.
This topic focuses on, but is not limited to,
• Research examining associative learning and synaptic long-term potentiation (LTP) mechanisms
• LTP and Pavlovian fear conditioning and how these induce similar changes in postsynaptic AMPA-type glutamate receptors
• presynaptic plasticity in the lateral nucleus and how this may contribute to fear memory formation
• Research investigating how an innocuous conditioned stimulus (CS) elicits fear responses after being associatively paired with an aversive unconditioned stimulus (US)
• How fear conditioning alters auditory CS-evoked responses in the LA (lateral nucleus of the amygdala) as well as through LTP induction
• Investigating how LTP-like associative processes occur during fear conditioning, and how these underlie the long-term associative plasticity that constitutes the memory of the conditioning experience.
• Hebbian plasticity in Fear Conditioning
Keywords: synaptic plasticity, phobias, response, conditioning
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.