Oral health is one of the main aspects of human health. A healthy oral function is conducive to maintaining good chewing, pronunciation, facial shape, and nutritional state, and can also give people confidence. In patients with malignant tumors, the main causes of osteonecrosis of the jaw (ONJ) are radiotherapy and chemotherapy. The primary diseases of patients with osteoradionecrosis of the jaw (ORNJ) are mainly nasopharyngeal cancer or oral cancer. Medication-related osteonecrosis of the Jaw (MRONJ) is a rare but serious drug complication. In these cases, radiotherapy and chemotherapy could lead to metabolic disorders of the jawbone, which can develop into ONJ without timely and appropriate intervention. In other cases, the ONJ is triggered by several mechanisms that result in no healing after teeth extraction and slowly evolve into jaw bone exposure and infection.
Although newly discovered characteristics of ONJ make it difficult to effectively treat, ongoing work on deciphering the pathophysiological mechanisms for different types of ONJ suggests novel treatment modalities. This Research Topic will therefore be devoted to the mechanisms of clinical management of ONJ. The goal of the current Research Topic is to assemble manuscripts (original articles or literature reviews) related to the pathogenesis and mechanism-based clinical treatment of ONJ. The submissions are supposed to consider :
• The underlying mechanisms of dental infections during chemotherapy or radiotherapy in cancer patients and its related treatment strategies
• Mechanisms of the development of bone microbiota, infection, and inflammation in ONJ and corresponding management
• Novel insights into the impact of different chemotherapy drugs on oral soft tissue
• Novel drugs or biomaterials targeting the mechanisms of ONJ initiation and deterioration
• The role of oral mucosa in the protection of the jaw bone
• Novel treatments to improve the state of the oral mucosa, based on immune modulation
• Auxiliary technologies employing physical or chemical means to enhance the effect of classic drugs for jaw bone necrosis
Topic Editor Ling Wu is the principal scientist for R&D of IVIEW Therapeutics, Inc. The other Topic Editors declare no competing interests concerning the Research Topic subject.
Oral health is one of the main aspects of human health. A healthy oral function is conducive to maintaining good chewing, pronunciation, facial shape, and nutritional state, and can also give people confidence. In patients with malignant tumors, the main causes of osteonecrosis of the jaw (ONJ) are radiotherapy and chemotherapy. The primary diseases of patients with osteoradionecrosis of the jaw (ORNJ) are mainly nasopharyngeal cancer or oral cancer. Medication-related osteonecrosis of the Jaw (MRONJ) is a rare but serious drug complication. In these cases, radiotherapy and chemotherapy could lead to metabolic disorders of the jawbone, which can develop into ONJ without timely and appropriate intervention. In other cases, the ONJ is triggered by several mechanisms that result in no healing after teeth extraction and slowly evolve into jaw bone exposure and infection.
Although newly discovered characteristics of ONJ make it difficult to effectively treat, ongoing work on deciphering the pathophysiological mechanisms for different types of ONJ suggests novel treatment modalities. This Research Topic will therefore be devoted to the mechanisms of clinical management of ONJ. The goal of the current Research Topic is to assemble manuscripts (original articles or literature reviews) related to the pathogenesis and mechanism-based clinical treatment of ONJ. The submissions are supposed to consider :
• The underlying mechanisms of dental infections during chemotherapy or radiotherapy in cancer patients and its related treatment strategies
• Mechanisms of the development of bone microbiota, infection, and inflammation in ONJ and corresponding management
• Novel insights into the impact of different chemotherapy drugs on oral soft tissue
• Novel drugs or biomaterials targeting the mechanisms of ONJ initiation and deterioration
• The role of oral mucosa in the protection of the jaw bone
• Novel treatments to improve the state of the oral mucosa, based on immune modulation
• Auxiliary technologies employing physical or chemical means to enhance the effect of classic drugs for jaw bone necrosis
Topic Editor Ling Wu is the principal scientist for R&D of IVIEW Therapeutics, Inc. The other Topic Editors declare no competing interests concerning the Research Topic subject.