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Abstract Submission Deadline 31 January 2023
Manuscript Submission Deadline 31 March 2023

Frailty, malnutrition, and body composition are considered as increasingly important risk-factors in transplantation oncology and in the surgical and multimodal treatment of hepato-pancreato-biliary cancers. The prevalence of malnutrition and pathological alterations of body composition are high both in ...

Frailty, malnutrition, and body composition are considered as increasingly important risk-factors in transplantation oncology and in the surgical and multimodal treatment of hepato-pancreato-biliary cancers. The prevalence of malnutrition and pathological alterations of body composition are high both in oncological cohorts as well as in liver transplant recipients. The overwhelming majority of studies of previous years investigated the effects of reduced muscle mass or sarcopenia, and demonstrated a robust association with inferior outcomes in various settings. The exact prognostic role of newer risk phenotypes such as myosteatosis and sarcopenic-obesity is being currently explored by various groups.

While an association between pathological body composition and inferior outcomes is consistently found in population-based studies at a certain timepoint, prospective studies examining muscle alterations longitudinally during liver disease evolution or in cancer are scarce. Based on this, it is yet to be explored whether changes in body composition are playing a causal or aggravating role or can be considered only as a result of a progressing critical illness and cancer. In particular, the underlying pathophysiological mechanisms remain partially unknown.

Meanwhile, there is accumulating evidence showing the positive effects of various interventions such as nutritional therapy, medical treatment, exercise and prehabilitation approaches in oncological cohorts and in patients with liver disease.

The goal of this Research topic is to publish original research, reviews & mini-reviews, clinical trials, expert opinions and perspectives on various aspects of malnutrition and body composition in the field of transplant oncology and in hepato-pancreato-biliary cancers.

We welcome submissions covering, but not limited to, the following themes:
- New preclinical and clinical data reporting on the prognostic role or mechanisms of body composition changes and malnutrition.
- Novel prognostic scores including body composition parameters or markers of malnutrition.
- Body composition, frailty and malnutrition in surgical outcomes.
- Body composition, frailty and malnutrition in oncological outcomes.
- Prehabilitation, exercise and nutritional therapies targeting body composition and malnutrition in liver disease and hepato-pancreato-biliary cancers.
- Next generation targeted therapies.

Important Note: Manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) will not be accepted in any of the sections of Frontiers in Oncology.

Keywords: body composition, malnutrition, transplant oncology, hepato, pancreato, biliary


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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