About this Research Topic
The Topic will host an overview of the most recent knowledge on enamel issued from the panel of international experts involved in Tooth Enamel IX meeting. Presentations of original data, key notes and opinions will be welcomed. The Topic will also host Tooth Enamel IX discussions and debates, highlighting changing paradigms, pointing out unsolved and challenge questions and profiling scientific issues and translational prospects. Enamel topic will be by nature transdisciplinary, at the frontiers between integrative cell biology, biochemistry and mineral chemistry. Scientific reports on this unique mineral architecture and the sequential molecular interactions leading extracellular self-assembly will associate physics, chemistry, biochemistry and original modelizations. This knowledge will open a window on innovative biomimetics of interest in regenerative medicine. Molecular networks leading amelogenesis will exploit vertebrate enamel biodiversity as a landmark to draw the evolution of genes important in morphogenesis and mineralization and encoding transcription factors, growth factors, matrix proteins or enzymes. Tissue-specific networks and pathways shared with a number of biological systems (clock genes, epithelial polarization/ion handling, cell niche dynamics, cell signaling,…) will be explored. This will give an overall picture of the multiple acellular, cellular and animal (essentially transgenic mice) models handled in the enamel field. In the same line of thoughts, lessons from isolated or syndromic, inherited and acquired enamel defects will gather enamel phenotypes, cell and matrix-omics and outline the emerging genomic frame of enamel quality. Indeed tooth enamel defects fingerprint historical and present gene-environment modifications in animal and human condition such as climate, nutrition, pollutants or fluoride exposures. This last fact is highly relevant in medicine and public health since poor tooth quality and mineral defects are one of the first human worldwide pathologies.
Keywords: Stem cell Differentiation, Evolution and Development, Cell models, Cell biology, Biomineralization, Matrix, Mineral, Mineral pathology, Amelogenesis Imperfecta, Caries
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