Spinal cord injury (SCI) is an overwhelming neurological disorder with high mortality and disability caused by a variety of factors that usually result in an irreversible sensorimotor function deficiency. Currently, although diverse therapeutic approaches are being tested to alleviate SCI and maximize neural regeneration, there is no effective treatment available for SCI. The possible reason could be that most therapeutic strategies have used treatments directed towards a single pathophysiological mechanism. However, SCI is an extremely multifaceted dynamic pathological process. Different mechanisms and the cross-talks among them might be involved in the multifaceted SCI dynamic pathological events. Therefore, it is necessary to elucidate the underlying mechanisms by which multi-target therapeutic approaches for the treatment of SCI with progressive multifaceted pathological change results in spinal cord regeneration. Meanwhile, Current target treatments to ameliorate SCI outcomes can be also promising for SCI individuals according to the tissue and cellular microenvironmental pathophysiology of SCI.
SCI is a complex pathological condition that evolves over time. The pathological mechanisms are involved in a multifaceted pathology after SCI, and finding effective treatment strategies poses a major challenge. The multi-target therapeutic approach might be efficient for spinal cord regeneration and functional recovery. The elucidation of the related cellular and molecular pathophysiology mechanisms underlying the occurrence of various unfavorable factors-induced SCI could not only deepen the understanding of the pathophysiological mechanism of SCI but also provide a novel theoretical basis for clarification of the precise molecular mechanisms in future clinical multitarget therapeutic applications.
This Research Topic warmly welcomes submissions in the form of Original Research or Review articles that aim to consolidate advances in the field of cellular and molecular pathophysiology mechanisms underlying spinal cord injury and technical and clinical studies related to the strategies for the treatment of CNS/PNS injuries. The potential contents would include, but not be limited to:
• Stem cells, cell-based therapy, gene therapy;
• Neuronal injury and regeneration from cellular to molecular perspective, including axonal regeneration, neuroplasticity, neural repair and replacement, neural circuit, nerve transplantation;
• Improvement of microenvironment includes melting glial scar, modulation of neuroinflammation, remyelination or neurotrophic signaling repair, neurovasculogenesis, synaptogenesis, and interactions of neural cells after SCI;
• Pharmacological treatment, animal model of spinal cord injury;
• Biomaterials, tissue engineering, neuromodulation or other innovative technologies and methods regarding the development of CNS/PNS injuries.
Spinal cord injury (SCI) is an overwhelming neurological disorder with high mortality and disability caused by a variety of factors that usually result in an irreversible sensorimotor function deficiency. Currently, although diverse therapeutic approaches are being tested to alleviate SCI and maximize neural regeneration, there is no effective treatment available for SCI. The possible reason could be that most therapeutic strategies have used treatments directed towards a single pathophysiological mechanism. However, SCI is an extremely multifaceted dynamic pathological process. Different mechanisms and the cross-talks among them might be involved in the multifaceted SCI dynamic pathological events. Therefore, it is necessary to elucidate the underlying mechanisms by which multi-target therapeutic approaches for the treatment of SCI with progressive multifaceted pathological change results in spinal cord regeneration. Meanwhile, Current target treatments to ameliorate SCI outcomes can be also promising for SCI individuals according to the tissue and cellular microenvironmental pathophysiology of SCI.
SCI is a complex pathological condition that evolves over time. The pathological mechanisms are involved in a multifaceted pathology after SCI, and finding effective treatment strategies poses a major challenge. The multi-target therapeutic approach might be efficient for spinal cord regeneration and functional recovery. The elucidation of the related cellular and molecular pathophysiology mechanisms underlying the occurrence of various unfavorable factors-induced SCI could not only deepen the understanding of the pathophysiological mechanism of SCI but also provide a novel theoretical basis for clarification of the precise molecular mechanisms in future clinical multitarget therapeutic applications.
This Research Topic warmly welcomes submissions in the form of Original Research or Review articles that aim to consolidate advances in the field of cellular and molecular pathophysiology mechanisms underlying spinal cord injury and technical and clinical studies related to the strategies for the treatment of CNS/PNS injuries. The potential contents would include, but not be limited to:
• Stem cells, cell-based therapy, gene therapy;
• Neuronal injury and regeneration from cellular to molecular perspective, including axonal regeneration, neuroplasticity, neural repair and replacement, neural circuit, nerve transplantation;
• Improvement of microenvironment includes melting glial scar, modulation of neuroinflammation, remyelination or neurotrophic signaling repair, neurovasculogenesis, synaptogenesis, and interactions of neural cells after SCI;
• Pharmacological treatment, animal model of spinal cord injury;
• Biomaterials, tissue engineering, neuromodulation or other innovative technologies and methods regarding the development of CNS/PNS injuries.
