Tissue damage is a leading cause of mortality worldwide, with consequences for both human health and the economy. Research over the past 20 years has uncovered several critical findings in the process of tissue injury and healing. Failure to heal is generally linked to underlying clinical conditions, such as vascular disease and stroke, which are frequently associated with healing pathologies. Moreover, tissue damage is an integrated response involving cell death, inflammation, and fibrosis, which requires further exploration of the underlying cellular and molecular mechanisms to improve the quality of tissue repair.
Recently, the development of multi-omics and high-resolution single cell omics has greatly facilitated the study of tissue damage mechanisms underlying which different cell types recruit and interact upon injury response. On the other hand, new findings on novel tissue engineering may provide insights into potential therapies for tissue repair.
This research topic aims to explore the mechanisms of tissue injury response, including inflammation, angiogenesis, fibrosis deposition, cell composition dynamics, and cell death in different organ systems. And studies regarding novel tissue engineering methods targeting tissue repair or regeneration are also welcome.
All article types accepted by Integrative Physiology section are welcome. Subtopics include but are not limited to the following:
• Exploration of novel mechanisms underlying tissue damage response, including inflammation, angiogenesis, fibrosis deposition, and cell death;
• Novel tissue engineering approaches targeting tissue repair;
• Metabolism-linked disorder in contribution to tissue damage;
• Multi-omics-based cell composition dynamics during tissue repair.
Tissue damage is a leading cause of mortality worldwide, with consequences for both human health and the economy. Research over the past 20 years has uncovered several critical findings in the process of tissue injury and healing. Failure to heal is generally linked to underlying clinical conditions, such as vascular disease and stroke, which are frequently associated with healing pathologies. Moreover, tissue damage is an integrated response involving cell death, inflammation, and fibrosis, which requires further exploration of the underlying cellular and molecular mechanisms to improve the quality of tissue repair.
Recently, the development of multi-omics and high-resolution single cell omics has greatly facilitated the study of tissue damage mechanisms underlying which different cell types recruit and interact upon injury response. On the other hand, new findings on novel tissue engineering may provide insights into potential therapies for tissue repair.
This research topic aims to explore the mechanisms of tissue injury response, including inflammation, angiogenesis, fibrosis deposition, cell composition dynamics, and cell death in different organ systems. And studies regarding novel tissue engineering methods targeting tissue repair or regeneration are also welcome.
All article types accepted by Integrative Physiology section are welcome. Subtopics include but are not limited to the following:
• Exploration of novel mechanisms underlying tissue damage response, including inflammation, angiogenesis, fibrosis deposition, and cell death;
• Novel tissue engineering approaches targeting tissue repair;
• Metabolism-linked disorder in contribution to tissue damage;
• Multi-omics-based cell composition dynamics during tissue repair.
