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Role of oxidative stress in cardiovascular diseases

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Background: There is a close relationship between increased Angiotensin II (Ang II) and oxidative stress in cardiovascular diseases. It is already known as one of the most important consequences of activation of the Ang II type 1 (AT1) receptor is enhanced nicotinamide adenine dinucleotide phosphate (NADPH) ...

Background: There is a close relationship between increased Angiotensin II (Ang II) and oxidative stress in cardiovascular diseases. It is already known as one of the most important consequences of activation of the Ang II type 1 (AT1) receptor is enhanced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity, eliciting the production of reactive oxygen species (ROS), especially the super-oxide anion (O2-). The brain is one of the Ang II targets most affected by oxidative stress. In fact, increased ROS actions in the central nervous system appear to be an important mechanism leading to deleterious sympathetic activation in hypertension and heart failure. Furthermore, increased oxidative stress systemically has been related to impairment of baroreceptor and renal function contributing to cardiovascular diseases. Therefore, a Research Topic in the Frontiers in Neuroscience regarding the role of oxidative stress in cardiovascular disorders will be a subject of interest for many readers.

In this Research Topic the authors will be encouraged to send papers regarding the importance of the oxidative stress in the cardiovascular system in health and disease. The source or sources of super-oxide formation in regions of the brain involved in cardiovascular control has not been determined; whether AT1 receptor activation can specifically increase ROS formation in cardiovascular or non-cardiovascular neurons or in glial cells or in endothelial cells remains to be established. Thus, longer-term activation of the AT1 receptor in the brain leading to increased oxidative stress may have the potential for deleterious positive- feedback effects of Ang II’s actions on the central nervous system, and this may play a major role cardiovascular diseases. Furthermore, the actions of oxidative stress outside the blood-brain barrier changing cardiovascular function will be addressed in this Research Topic. Therefore, a Research Topic in the Frontiers in Neuroscience regarding the role of oxidative stress in cardiovascular diseases will be a subject of interest for many readers.


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