Cardiovascular disease has a significant burden at a population level and is a leading cause of mortality. However, there is now growing evidence to suggest that traditional risk factors may not be the primary driver in certain subgroups of patients with the disease. The relatively new field of cardiovascular immunology encompasses a wide range of themes including chronic vessel inflammation, alternated lipid metabolism, and abnormal innate and adaptive immune responses. Furthermore, there is an increased incidence of cardiovascular events in patients with chronic infections, autoimmune and inflammatory disorders that is not accounted for by classical risk factors. More directly, autoimmune responses can be focused on the vessel architecture itself (in the case of vasculitis). There is now a growing understanding of the interplay between the immune system and vasculature in disease and how this may provide new insight into non-classical causes of cardiac and vascular disease, thus opening avenues for potential novel therapeutic targets in the future.
The goal of this Research Topic is to promote the latest advances in the field of cardiovascular immunology and inflammation and how this links to novel risk factors and stratification. The aim is to promote a greater understanding of the interplay between the cardiovascular and immune systems, and how this may be targeted by direct immunological therapies to improve long-term outcomes, in particular in those with abnormal immune activation from either a chronic immunological disease or persistent infection.
We encourage the submission of both original research and review papers focusing on the immunological drivers of vessel inflammation in atherosclerosis and vasculitis; endothelial dysfunction in autoimmune/inflammatory disorders, and clinical studies relating to cardiovascular outcomes in patients with immunological abnormalities (relating to chronic infection, autoimmune disorders, and immunodeficiency). We welcome manuscripts that cover, but are not limited to, the following sub-topics:
• The role of the adaptive immune system in cardiovascular inflammation
• The role of monocytes, macrophages and the innate immune response in cardiovascular inflammation
• Immune drivers of endothelial dysfunction in health and autoimmunity
• Novel biomarkers and imaging for vascular injury and atherosclerosis
• Epidemiology of cardiovascular disease in patients with chronic infections, immunodeficiency and autoimmune disorders
• Immunometabolism and altered immune homeostasis in cardiovascular disease
• Lipid disorders in autoimmunity, inflammation and chronic infection
• Immune ageing and senescence in cardiovascular disorders
• Animal models of vascular inflammation / vasculitis
• Factors associated with increased risk of atherosclerosis in autoimmune disorders (such a systemic lupus erythematosus, rheumatoid arthritis, psoriasis and multiple sclerosis)
Cardiovascular disease has a significant burden at a population level and is a leading cause of mortality. However, there is now growing evidence to suggest that traditional risk factors may not be the primary driver in certain subgroups of patients with the disease. The relatively new field of cardiovascular immunology encompasses a wide range of themes including chronic vessel inflammation, alternated lipid metabolism, and abnormal innate and adaptive immune responses. Furthermore, there is an increased incidence of cardiovascular events in patients with chronic infections, autoimmune and inflammatory disorders that is not accounted for by classical risk factors. More directly, autoimmune responses can be focused on the vessel architecture itself (in the case of vasculitis). There is now a growing understanding of the interplay between the immune system and vasculature in disease and how this may provide new insight into non-classical causes of cardiac and vascular disease, thus opening avenues for potential novel therapeutic targets in the future.
The goal of this Research Topic is to promote the latest advances in the field of cardiovascular immunology and inflammation and how this links to novel risk factors and stratification. The aim is to promote a greater understanding of the interplay between the cardiovascular and immune systems, and how this may be targeted by direct immunological therapies to improve long-term outcomes, in particular in those with abnormal immune activation from either a chronic immunological disease or persistent infection.
We encourage the submission of both original research and review papers focusing on the immunological drivers of vessel inflammation in atherosclerosis and vasculitis; endothelial dysfunction in autoimmune/inflammatory disorders, and clinical studies relating to cardiovascular outcomes in patients with immunological abnormalities (relating to chronic infection, autoimmune disorders, and immunodeficiency). We welcome manuscripts that cover, but are not limited to, the following sub-topics:
• The role of the adaptive immune system in cardiovascular inflammation
• The role of monocytes, macrophages and the innate immune response in cardiovascular inflammation
• Immune drivers of endothelial dysfunction in health and autoimmunity
• Novel biomarkers and imaging for vascular injury and atherosclerosis
• Epidemiology of cardiovascular disease in patients with chronic infections, immunodeficiency and autoimmune disorders
• Immunometabolism and altered immune homeostasis in cardiovascular disease
• Lipid disorders in autoimmunity, inflammation and chronic infection
• Immune ageing and senescence in cardiovascular disorders
• Animal models of vascular inflammation / vasculitis
• Factors associated with increased risk of atherosclerosis in autoimmune disorders (such a systemic lupus erythematosus, rheumatoid arthritis, psoriasis and multiple sclerosis)