In the central nervous system (CNS), myelinated nerve fibers have enabled fast and efficient transduction of electrical signals by saltatory conduction. Oligodendrocytes are the myelinating cells of the CNS during development and throughout adulthood. They result from a complex and well controlled process of activation, proliferation, migration, and differentiation of oligodendrocyte progenitor cells (OPCs) from the germinative niches of the CNS. However, in the patients of demyelinating disease such as multiple system atrophy (MSA) and Krabbe disease, the loss of oligodendrocytes leads to demyelination and brain, especially cerebellar, dysfunction. Thus, the insight mechanism of myelination and oligodendrocyte development under physiological conditions or, demyelination and remyelination under pathological conditions, is important for further therapeutic target exploring.
The field of myelin in the developing brain and related disease rapidly grew during the last decades. The importance of this theme is highlighted by current research bringing to attention the significant roles that oligodendrocyte development and myelination play in early brain development. Furthermore, the mechanisms for pathological process such as disruption of myelin development in the new born baby with Krabbe disease, or the death of matured oligodendrocyte in multiple sclerosis and multiple system atrophy are also attracting a lot of attention. In this Research Topic, we encourage researchers to describe novel insight findings towards the progress of oligodendrocyte and myelin development in the early development of brain white matter as well as the mechanisms of demyelination and brain dysfunction in neurodegeneration. We also welcome contributions that look into the novel therapeutic approaches towards myelin diseases.
This topic focuses on, but is not limited to studies on:
• New findings focused on early development of white matter in brain or spinal cord.
• Pathological studies focus on the myelin morphology and oligodendrocyte development in early or late stage of any neurodegenerative disorders.
• Molecular mechanisms of white matter dysfunction in multiple sclerosis, multiple system atrophy, Krabbe disease or other related disease.
• Novel therapeutic approaches towards myelin disease.
• Myelin disruption in neurodevelopmental disorders.
We welcome the submission of all types of articles i.e., Original Research, Review, Methods, and Perspective article.
In the central nervous system (CNS), myelinated nerve fibers have enabled fast and efficient transduction of electrical signals by saltatory conduction. Oligodendrocytes are the myelinating cells of the CNS during development and throughout adulthood. They result from a complex and well controlled process of activation, proliferation, migration, and differentiation of oligodendrocyte progenitor cells (OPCs) from the germinative niches of the CNS. However, in the patients of demyelinating disease such as multiple system atrophy (MSA) and Krabbe disease, the loss of oligodendrocytes leads to demyelination and brain, especially cerebellar, dysfunction. Thus, the insight mechanism of myelination and oligodendrocyte development under physiological conditions or, demyelination and remyelination under pathological conditions, is important for further therapeutic target exploring.
The field of myelin in the developing brain and related disease rapidly grew during the last decades. The importance of this theme is highlighted by current research bringing to attention the significant roles that oligodendrocyte development and myelination play in early brain development. Furthermore, the mechanisms for pathological process such as disruption of myelin development in the new born baby with Krabbe disease, or the death of matured oligodendrocyte in multiple sclerosis and multiple system atrophy are also attracting a lot of attention. In this Research Topic, we encourage researchers to describe novel insight findings towards the progress of oligodendrocyte and myelin development in the early development of brain white matter as well as the mechanisms of demyelination and brain dysfunction in neurodegeneration. We also welcome contributions that look into the novel therapeutic approaches towards myelin diseases.
This topic focuses on, but is not limited to studies on:
• New findings focused on early development of white matter in brain or spinal cord.
• Pathological studies focus on the myelin morphology and oligodendrocyte development in early or late stage of any neurodegenerative disorders.
• Molecular mechanisms of white matter dysfunction in multiple sclerosis, multiple system atrophy, Krabbe disease or other related disease.
• Novel therapeutic approaches towards myelin disease.
• Myelin disruption in neurodevelopmental disorders.
We welcome the submission of all types of articles i.e., Original Research, Review, Methods, and Perspective article.
