Neurotrophins (NGF, BDNF, NT3 and NT4) and their high (Trk receptors) and low affinity (p75 NTR) receptors play a key role in the development and maintenance of the central and peripheral nervous systems, controlling neuronal growth, differentiation and survival. The main diseases and disorders of the central and peripheral nervous system, such as Alzheimer's, Parkinson's, autism spectrum disorders, depression and peripheral neuropathy, among others, are based on altered expression of neurotrophins and their receptors. Knowledge of the role of neurotrophins and their receptors is of extraordinary importance to understand the origin of these diseases and disorders and to design new therapeutic approaches based on their mechanisms of action.The objective of this Research Topic is to highlight the latest findings on key aspects of the role of neurotrophins and their receptors in central and peripheral neuronal system development, the molecular mechanisms controlling neuronal migration and differentiation, neuronal circuitry formation and synaptic plasticity, higlighting the studies focused on diseases and disorders of the central and peripheral nervous system in humans and the potential use of neurotrophins and their receptors as therapeutic targets.In this Research Topic, we encourage the submission of original research, methods, perspectives, and reviews that explore the molecular mechanisms underlying the role of neurotrophins and their receptors in normal and pathological conditions and their potential therapeutic effect.We especially welcome submissions of articles on the following sub-topics:- Molecular and cellular mechanisms governed by neurotrophins and their receptors involved in the development of the central and peripheral nervous system.- Diseases, disorders and conditions of the central and peripheral nervous system in which neurotrophins and their receptors play a key role.- Potential use of neurotrophins, Trk receptors or molecules related to them as potential therapeutic agents in diseases of the central and peripheral nervous system.
Neurotrophins (NGF, BDNF, NT3 and NT4) and their high (Trk receptors) and low affinity (p75 NTR) receptors play a key role in the development and maintenance of the central and peripheral nervous systems, controlling neuronal growth, differentiation and survival. The main diseases and disorders of the central and peripheral nervous system, such as Alzheimer's, Parkinson's, autism spectrum disorders, depression and peripheral neuropathy, among others, are based on altered expression of neurotrophins and their receptors. Knowledge of the role of neurotrophins and their receptors is of extraordinary importance to understand the origin of these diseases and disorders and to design new therapeutic approaches based on their mechanisms of action.The objective of this Research Topic is to highlight the latest findings on key aspects of the role of neurotrophins and their receptors in central and peripheral neuronal system development, the molecular mechanisms controlling neuronal migration and differentiation, neuronal circuitry formation and synaptic plasticity, higlighting the studies focused on diseases and disorders of the central and peripheral nervous system in humans and the potential use of neurotrophins and their receptors as therapeutic targets.In this Research Topic, we encourage the submission of original research, methods, perspectives, and reviews that explore the molecular mechanisms underlying the role of neurotrophins and their receptors in normal and pathological conditions and their potential therapeutic effect.We especially welcome submissions of articles on the following sub-topics:- Molecular and cellular mechanisms governed by neurotrophins and their receptors involved in the development of the central and peripheral nervous system.- Diseases, disorders and conditions of the central and peripheral nervous system in which neurotrophins and their receptors play a key role.- Potential use of neurotrophins, Trk receptors or molecules related to them as potential therapeutic agents in diseases of the central and peripheral nervous system.