The subchondral bone layer is a microstructure unit composed of several cells such as bone lineage cells, bone matrix, immune cells, cytokines, blood vessels and any other, which plays a crucial role in maintaining homeostasis about ”Bone-cartilage” micro-environment. Various inflammatory articular pathologies, represented by rheumatoid arthritis (RA), osteoarthritis (OA), temporomandibular joint osteoarthritis (TMJOA), spondyloarthritis (SpA) contribute to dramatic changes in the cellular and extracellular components of the subchondral bone microenvironment through modulating subchondral bone remodeling, inflammatory responses, oxidative stress, mechanotransduction and neovascularization. Hence, the subchondral bone microenvironment may provide a potential therapeutic target for numerous related symptoms associated with joint diseases. In addition, it is necessary to elucidate the network relationship of subchondral bone microenvironment, including chondrocyte (CC)-osteoclast (OC)-osteocyte coupling effects, inflammatory responses or angiogenesis. Besides, further investigations about the mechanisms of articular dysfunction-related pain and any other related symptoms through modulating the homeostasis of subchondral bone microenvironment are also awaited.
This Research Topic aims to illustrate the critical role of subchondral bone microenvironment in the progression and prevention for the arthropathies (OA, RA, SpA and etc). In is urgent to investigate the crucial coupling effects among several kinds of cells in subchondral bone microenvironment so as to get hang of novel mechanisms in this process. This Research Topic is also devoted to finding out the potential therapeutic targets by modulating the homeostasis of subchondral bone microenvironment to treat arthropathies.
We welcome submissions covering, but not limited to, the following aspects:
• Promising mechanisms about regulating the dynamic balance of subchondral bone microenvironment.
• The coupling effects among several kinds of cells (chondrocytes, Hypertrophic chondrocytes, vascular endothelium, osteoblast, osteoclast, osteocytes or any other immunological cells) in subchondral bone microenvironment during progression of arthropathies (OA, RA, SpA and etc).
• Novel mechanisms about the pain and any other related symptoms could be occurred via destroying the subchondral bone microenvironment during progression of arthropathies (OA, RA, SpA and etc).
• Single-cell analysis about the composition and potential correlation in subchondral bone microenvironment during arthropathies (OA, RA, SpA and etc).
• The positive and negative effects of mechanical changes in the subchondral bone microenvironment during the progression and treatments for arthropathies (OA, RA, SpA and etc).
• Effective therapeutic strategies about the treatment for arthropathies (OA, RA, SpA and etc) through modulating the homeostasis of subchondral bone microenvironment.
The subchondral bone layer is a microstructure unit composed of several cells such as bone lineage cells, bone matrix, immune cells, cytokines, blood vessels and any other, which plays a crucial role in maintaining homeostasis about ”Bone-cartilage” micro-environment. Various inflammatory articular pathologies, represented by rheumatoid arthritis (RA), osteoarthritis (OA), temporomandibular joint osteoarthritis (TMJOA), spondyloarthritis (SpA) contribute to dramatic changes in the cellular and extracellular components of the subchondral bone microenvironment through modulating subchondral bone remodeling, inflammatory responses, oxidative stress, mechanotransduction and neovascularization. Hence, the subchondral bone microenvironment may provide a potential therapeutic target for numerous related symptoms associated with joint diseases. In addition, it is necessary to elucidate the network relationship of subchondral bone microenvironment, including chondrocyte (CC)-osteoclast (OC)-osteocyte coupling effects, inflammatory responses or angiogenesis. Besides, further investigations about the mechanisms of articular dysfunction-related pain and any other related symptoms through modulating the homeostasis of subchondral bone microenvironment are also awaited.
This Research Topic aims to illustrate the critical role of subchondral bone microenvironment in the progression and prevention for the arthropathies (OA, RA, SpA and etc). In is urgent to investigate the crucial coupling effects among several kinds of cells in subchondral bone microenvironment so as to get hang of novel mechanisms in this process. This Research Topic is also devoted to finding out the potential therapeutic targets by modulating the homeostasis of subchondral bone microenvironment to treat arthropathies.
We welcome submissions covering, but not limited to, the following aspects:
• Promising mechanisms about regulating the dynamic balance of subchondral bone microenvironment.
• The coupling effects among several kinds of cells (chondrocytes, Hypertrophic chondrocytes, vascular endothelium, osteoblast, osteoclast, osteocytes or any other immunological cells) in subchondral bone microenvironment during progression of arthropathies (OA, RA, SpA and etc).
• Novel mechanisms about the pain and any other related symptoms could be occurred via destroying the subchondral bone microenvironment during progression of arthropathies (OA, RA, SpA and etc).
• Single-cell analysis about the composition and potential correlation in subchondral bone microenvironment during arthropathies (OA, RA, SpA and etc).
• The positive and negative effects of mechanical changes in the subchondral bone microenvironment during the progression and treatments for arthropathies (OA, RA, SpA and etc).
• Effective therapeutic strategies about the treatment for arthropathies (OA, RA, SpA and etc) through modulating the homeostasis of subchondral bone microenvironment.