Neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis are characterized by the progressive loss of structure or function of the neuron. It can involve motor and cognitive function and the leading causes affecting the patient's quality of life. As people live longer, the incidence of neurodegenerative disorders will also increase. The pathogenesis of neurodegenerative disorders is complex and still mostly unclear. Inherited genetic variants, epigenetic changes, and environmental factors increase the risk of developing neurodegenerative diseases. Along with the wide application of new sequencing technologies, more and more evidence has suggested the essential role of genetic background in the susceptibility of neurodegenerative disorders. However, many genetic mechanisms in neurodegenerative diseases need more in-depth research.
This Research Topic aims to expand the current knowledge on the genetic background underlying Parkinson's disease, Alzheimer's disease, dystonia, and amyotrophic lateral sclerosis. Further work would be appreciated in discovering novel risk variants, mechanisms, and pathways involved in neurodegenerative diseases.
This Research Topic welcomes the submission of Original Research, Methods, Review, and Brief Report, with a particular interest in the following topics:
- Genes associated with neurodegenerative diseases
- Potential therapeutic targets for neurodegenerative diseases
- Molecular pathology studies based on animal models
- Epigenetic mechanisms in neurodegenerative diseases
Neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis are characterized by the progressive loss of structure or function of the neuron. It can involve motor and cognitive function and the leading causes affecting the patient's quality of life. As people live longer, the incidence of neurodegenerative disorders will also increase. The pathogenesis of neurodegenerative disorders is complex and still mostly unclear. Inherited genetic variants, epigenetic changes, and environmental factors increase the risk of developing neurodegenerative diseases. Along with the wide application of new sequencing technologies, more and more evidence has suggested the essential role of genetic background in the susceptibility of neurodegenerative disorders. However, many genetic mechanisms in neurodegenerative diseases need more in-depth research.
This Research Topic aims to expand the current knowledge on the genetic background underlying Parkinson's disease, Alzheimer's disease, dystonia, and amyotrophic lateral sclerosis. Further work would be appreciated in discovering novel risk variants, mechanisms, and pathways involved in neurodegenerative diseases.
This Research Topic welcomes the submission of Original Research, Methods, Review, and Brief Report, with a particular interest in the following topics:
- Genes associated with neurodegenerative diseases
- Potential therapeutic targets for neurodegenerative diseases
- Molecular pathology studies based on animal models
- Epigenetic mechanisms in neurodegenerative diseases
