There is a requirement for searching and expanding new metal-based antitumor factors with specific target side effects, less toxicity, and better activity. It is well-known that DNA is the primary antitumor purpose, which is based on the DNA adducts formation with anticancer drugs.
The binding properties of the metal complexes to serum albumins has a significant effect on the stability, toxicity, metabolism, distribution, and absorption of anticancer agents. Investigating serum albumin-complex binding can provide valued information for the pharmacokinetics of this compound, so be valued for the design and screening of drugs.
Lanthanide complexes are important matters as fluorescence sensors or probes for the selective discovery of biomacromolecules. Also, lanthanide complexes have shown unique biological activities, and thus, they have several substantial roles in the therapeutic and pharmaceutical fields, including antitumor, antibacterial, fungicidal, anti-inflammatory, and anticoagulant activities.
Based on the potential anticancer properties of lanthanide complexes, we focused on the synthesis of new complexes, especially lanthanide complexes. Then, new complexes are isolated and characterized via elemental analysis, single-crystal X-ray diffraction, NMR, TG and FT-IR, fluorescence, and UV-vis spectroscopy. Also, the DFT calculations carried out the determination of the optimized structure of the ligand and its complexes. Then, the various biological applications of these complexes are investigated, including: (I) Study the complex binding properties with DNA and serum albumin proteins via circular dichroism (CD) spectroscopy, UV-vis absorption spectroscopy, viscosity measurements, and fluorescence spectroscopy. (II) DNA cleavage evaluation of these complexes. (III) The evaluation of the complex antimicrobial properties against Gram-positive bacteria and Gram-negative bacteria. (IV) Synthesis, and characterization of Starch and lipid nano-encapsulated complexes. (V) Studies of the in vitro cytotoxic activity of the complexes and their encapsulated forms against cancer and standard cell lines. (VI) Molecular docking studies of the interactions of the complexes with DNA and serum albumin proteins.
The implementation of rare earth complexes as in vitro biomarkers and, in particular, binding probes is of considerable interest, and substantial progress can be expected in the future.
We welcome the submission of Original Research, Review, Mini-Review and Perspective articles on themes that include, but not limited to:
• Synthesis of new complexes, especially lanthanide complexes
• Characterization of new complexes via elemental analysis, single-crystal X-ray diffraction, NMR, TG and FT-IR, fluorescence, and UV-vis spectroscopy
• Determination of the optimized structure of the complexes by the DFT calculations
• Investigation of the various biological applications of these complexes, including:
• Study the complex binding properties with DNA and serum albumin proteins via circular dichroism (CD) spectroscopy, UV-vis absorption spectroscopy, viscosity measurements, and fluorescence spectroscopy
• DNA cleavage evaluation of these complexes
• The evaluation of the complex antimicrobial properties against Gram-positive bacteria and Gram-negative bacteria
• Synthesis, and characterization of Starch and lipid nano-encapsulated complexes
• Studies of the in vitro cytotoxic activity of the complexes and their encapsulated forms against cancer and standard cell lines
• Molecular docking studies of the interactions of the complexes with DNA and proteins
There is a requirement for searching and expanding new metal-based antitumor factors with specific target side effects, less toxicity, and better activity. It is well-known that DNA is the primary antitumor purpose, which is based on the DNA adducts formation with anticancer drugs.
The binding properties of the metal complexes to serum albumins has a significant effect on the stability, toxicity, metabolism, distribution, and absorption of anticancer agents. Investigating serum albumin-complex binding can provide valued information for the pharmacokinetics of this compound, so be valued for the design and screening of drugs.
Lanthanide complexes are important matters as fluorescence sensors or probes for the selective discovery of biomacromolecules. Also, lanthanide complexes have shown unique biological activities, and thus, they have several substantial roles in the therapeutic and pharmaceutical fields, including antitumor, antibacterial, fungicidal, anti-inflammatory, and anticoagulant activities.
Based on the potential anticancer properties of lanthanide complexes, we focused on the synthesis of new complexes, especially lanthanide complexes. Then, new complexes are isolated and characterized via elemental analysis, single-crystal X-ray diffraction, NMR, TG and FT-IR, fluorescence, and UV-vis spectroscopy. Also, the DFT calculations carried out the determination of the optimized structure of the ligand and its complexes. Then, the various biological applications of these complexes are investigated, including: (I) Study the complex binding properties with DNA and serum albumin proteins via circular dichroism (CD) spectroscopy, UV-vis absorption spectroscopy, viscosity measurements, and fluorescence spectroscopy. (II) DNA cleavage evaluation of these complexes. (III) The evaluation of the complex antimicrobial properties against Gram-positive bacteria and Gram-negative bacteria. (IV) Synthesis, and characterization of Starch and lipid nano-encapsulated complexes. (V) Studies of the in vitro cytotoxic activity of the complexes and their encapsulated forms against cancer and standard cell lines. (VI) Molecular docking studies of the interactions of the complexes with DNA and serum albumin proteins.
The implementation of rare earth complexes as in vitro biomarkers and, in particular, binding probes is of considerable interest, and substantial progress can be expected in the future.
We welcome the submission of Original Research, Review, Mini-Review and Perspective articles on themes that include, but not limited to:
• Synthesis of new complexes, especially lanthanide complexes
• Characterization of new complexes via elemental analysis, single-crystal X-ray diffraction, NMR, TG and FT-IR, fluorescence, and UV-vis spectroscopy
• Determination of the optimized structure of the complexes by the DFT calculations
• Investigation of the various biological applications of these complexes, including:
• Study the complex binding properties with DNA and serum albumin proteins via circular dichroism (CD) spectroscopy, UV-vis absorption spectroscopy, viscosity measurements, and fluorescence spectroscopy
• DNA cleavage evaluation of these complexes
• The evaluation of the complex antimicrobial properties against Gram-positive bacteria and Gram-negative bacteria
• Synthesis, and characterization of Starch and lipid nano-encapsulated complexes
• Studies of the in vitro cytotoxic activity of the complexes and their encapsulated forms against cancer and standard cell lines
• Molecular docking studies of the interactions of the complexes with DNA and proteins