Aging of human skin is a dynamic and multifactorial process that is a consequence of both intrinsic aging and photoaging. Intrinsic aging is attributed to chronological damage caused by slow and irreversible tissue degeneration, whereas photoaging is primarily the result of chronic ultraviolet (UV) exposure. Photoaged skin exhibits more dramatic histological and molecular changes in epidermis, dermis, and subcutaneous fat, as well as morphologically coarser wrinkles, severe dyspigmentation, and telangiectasia. Mechanistically, genetic and epigenetic changes in skin aging lead to the impairment of skin barrier, extracellular matrix, autophagy, neuro-endocrinology, metabolism, and cellular senescence.
Various anti-aging preventive and therapeutic interventions such as photoprotection, cosmeceuticals, topical agents, nutraceuticals, and energy-based devices are being developed and employed. These efforts will allow us to better understand the physiology of aging skin, and eventually aim at preventing and reversing skin aging and aging-related skin pathologies, including wound healing and skin cancer.
This article collection will include the review and original contributions regarding physiology, prevention, and management of skin aging.
Even though abstract submission is not mandatory, we encourage all interested researchers to submit an abstract before submitting their manuscript. Abstracts do not have to coincide with the final abstract of the manuscripts.
The Research Topic is part of the Frontiers in Physiology Healthy Aging series. The Research Topic will support #SDG3 Good Health and Well Being, #SDG10 Reduced Inequalities as well as #SDG11 Sustainable cities and communities.
Prof Anna Chien declares the following conflicts of interest:
"Amore Pacific", Investigator, Grants/Research Funding
"Boots", Investigator, Grants/Research Funding
"UpToDate", Inc, Honoraria.
The others topic editors declare no conflict of interest.
Aging of human skin is a dynamic and multifactorial process that is a consequence of both intrinsic aging and photoaging. Intrinsic aging is attributed to chronological damage caused by slow and irreversible tissue degeneration, whereas photoaging is primarily the result of chronic ultraviolet (UV) exposure. Photoaged skin exhibits more dramatic histological and molecular changes in epidermis, dermis, and subcutaneous fat, as well as morphologically coarser wrinkles, severe dyspigmentation, and telangiectasia. Mechanistically, genetic and epigenetic changes in skin aging lead to the impairment of skin barrier, extracellular matrix, autophagy, neuro-endocrinology, metabolism, and cellular senescence.
Various anti-aging preventive and therapeutic interventions such as photoprotection, cosmeceuticals, topical agents, nutraceuticals, and energy-based devices are being developed and employed. These efforts will allow us to better understand the physiology of aging skin, and eventually aim at preventing and reversing skin aging and aging-related skin pathologies, including wound healing and skin cancer.
This article collection will include the review and original contributions regarding physiology, prevention, and management of skin aging.
Even though abstract submission is not mandatory, we encourage all interested researchers to submit an abstract before submitting their manuscript. Abstracts do not have to coincide with the final abstract of the manuscripts.
The Research Topic is part of the Frontiers in Physiology Healthy Aging series. The Research Topic will support #SDG3 Good Health and Well Being, #SDG10 Reduced Inequalities as well as #SDG11 Sustainable cities and communities.
Prof Anna Chien declares the following conflicts of interest:
"Amore Pacific", Investigator, Grants/Research Funding
"Boots", Investigator, Grants/Research Funding
"UpToDate", Inc, Honoraria.
The others topic editors declare no conflict of interest.